Aprepitant Impurity 76 CAS CATO-C4X-114176
| CAS No. | CATO-C4X-114176 |
| Molecular Formula | C10H8F6O |
| Molecular Weight | 258.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Aprepitant Impurity 76 (CAS CATO-C4X-114176, C10H8F6O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Aprepitant Impurity 76 (C10H8F6O) contains a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 258.16 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H8F6O |
| Molecular Weight | 258.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
Related Aprepitant Standards
- Aprepitant Impurity 32 (CAS 225920-05-8)
- Aprepitant Impurity 33 (CAS 1265177-56-7)
- Aprepitant Impurity 38 (CAS 127852-28-2)
- Aprepitant Impurity 45 (CAS 364-47-6)
- Aprepitant impurity 28 (CAS 479679-98-6)
- Aprepitant Impurity 34 (CAS 30071-93-3)
- Aprepitant Impurity 75 (CAS 240489-98-9)
- Aprepitant impurity 50 (CAS 349-59-7)
Recommended Standards
- 4-(2,2,3,3-Tetrafluoropropoxy)Phthalonitrile (CAS 121190-46-3)
- 2-(4-fluorophenyl)-6-(trifluoromethyl)pyrimidin-4(3H)-one (CAS 1239765-81-1)
- 5-(4-Fluoro-3-(trifluoromethyl)phenyl)pyrimidin-2-ol (CAS 1261904-80-6)
- 5-(2-Fluoro-3-(trifluoromethyl)phenyl)pyrimidin-2-ol (CAS 1261987-33-0)
- Dasatinib Impurity 72 (CAS CATO-C4X-160772)
- Naproxen EP Impurity C (CAS 84236-26-0)
- Regadenoson Impurity 4 (CAS CATO-C4X-19854)
- (S)-2-(Methyl(1-methylpiperidin-3-yl)amino)acetic acid (CAS 1354002-73-5)
- Ethyl 4-chloro-[2,2'-bipyrimidine]-5-carboxylate (CAS 432521-55-6)
- 3-chloro-5-[(4-fluorophenyl)methyl]-1,2,4-oxadiazole (CAS 1393562-57-6)
- 4-(((4-Allyl-5-(2-(3-methyl-5-(trifluoromethyl)-1H-pyrazol-1-yl)thiazol-4-yl)-4H-1,2,4-triazol-3-yl)thio)methyl)benzoic acid (CAS 956356-94-8)
- 4-(4-Chlorophenyl)-5-(methylsulfonyl)-1,2,3-thiadiazole (CAS 1708037-23-3)
- tert-Butyl spiro[4,5-dihydro-1H-cyclopenta[c]pyrazole-6,4'-piperidine]-1'-carboxylate (CAS 1341035-84-4)
- Neuropeptide S (human) (CAS 412938-67-1)
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