Aprepitant Impurity 34 CAS 30071-93-3
| CAS No. | 30071-93-3 |
| Molecular Formula | C10H6F6O |
| Molecular Weight | 256.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Aprepitant Impurity 34 (CAS 30071-93-3, C10H6F6O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Aprepitant Impurity 34 (C10H6F6O) contains a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 256.14 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H6F6O |
| Molecular Weight | 256.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1965 |
| Halogen Content | F-containing |
Related Aprepitant Standards
- Aprepitant Impurity 75 (CAS 240489-98-9)
- Aprepitant impurity 28 (CAS 479679-98-6)
- Aprepitant Impurity 32 (CAS 225920-05-8)
- Aprepitant Impurity 33 (CAS 1265177-56-7)
- Aprepitant Impurity 38 (CAS 127852-28-2)
- Aprepitant Impurity 45 (CAS 364-47-6)
- Aprepitant Impurity 76 (CAS CATO-C4X-114176)
- Aprepitant impurity 50 (CAS 349-59-7)
Recommended Standards
- 2138-34-3 1-(4-bromophenyl)-3-(dimethylamino)propan-1-one DTXSID40276782 (CAS 2138-34-3)
- N-t-Butyl 3-bromobenzamide (CAS 42498-39-5)
- 3-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propan-1-ol (CAS 1000802-50-5)
- N-Isobutyl 2-bromobenzamide (CAS 88358-26-3)
- Vildagliptin Impurity N16 (CAS 918830-94-1)
- Ganirelix lmpurity 12 (CAS CATO-C4X-237312)
- Phytomenadione/Vitamin K1 Impurity 86 (CAS CATO-C4X-220786)
- Quinuclidin-4-ol (CAS 26458-74-2)
- 1,4-Dioxa-7-azaspiro[4.4]nonane (CAS 176-33-0)
- tert-Butyl (1-((S)-2-amino-1-(2,5-dimethoxyphenyl)ethyl)pyrrolidin-3-yl)carbamate (CAS 1217541-47-3)
- 5-(4-Bromophenyl)-4-methylthiophene-2-carboxylic acid (CAS 62404-05-1)
- 2-(4-Fluorobenzyl)butanoic acid (CAS 1017146-79-0)
- N-(1-(furan-2-yl)ethyl)propionamide (CAS 1147388-63-3)
- Semaglutide Impurity 125 xTFA Salt (CAS CATO-C4X-2226125)
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