Dapagliflozin Impurity 198 CAS 2454263-77-3
| CAS No. | 2454263-77-3 |
| Molecular Formula | C15H14BrClO |
| Molecular Weight | 325.63 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Dapagliflozin Impurity 198 (C15H14BrClO) contains a hydroxyl group, an ether linkage, chlorine/bromine substitution, a polycyclic aromatic system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Dapagliflozin Impurity 198 (CAS 2454263-77-3) is a certified pharmaceutical impurity reference standard with the molecular formula C15H14BrClO and a molecular weight of 325.63 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H14BrClO |
| Molecular Weight | 325.63 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | Cl/Br-containing |
Related Dapagliflozin Standards
- Dapagliflozin Impurity 10 (CAS 461432-23-5)
- Dapagliflozin Impurity 121 (CAS CATO-C4X-1138121)
- Dapagliflozin Impurity 122 (CAS CATO-C4X-1138122)
- Dapagliflozin Impurity 123 (CAS CATO-C4X-1138123)
- Dapagliflozin Impurity 141 (CAS 1629862-21-0)
- Dapagliflozin Impurity 142 (CAS CATO-C4X-1138142)
- Dapagliflozin Impurity 151 (CAS CATO-C4X-1138151)
- Dapagliflozin Impurity 183 (CAS CATO-C4X-1138183)
Recommended Standards
- Dapagliflozin Impurity 87 (CAS CATO-C4X-113887)
- Dapagliflozin Impurity 88 (CAS CATO-C4X-113888)
- Dapagliflozin Impurity 89 (CAS CATO-C4X-113889)
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- Cefotiam Impurity 27 (CAS CATO-C4X-120427)
- Levofloxacin Impurity 94 (CAS CATO-C4X-137194)
- Alvimopan Impurity 2 (CAS 6967-88-0)
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