Celecoxib Impurity 34 CAS 24939-24-0
| CAS No. | 24939-24-0 |
| Molecular Formula | C6H6ClNO2S |
| Molecular Weight | 191.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Celecoxib Impurity 34 (C6H6ClNO2S) contains an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Celecoxib Impurity 34 (CAS 24939-24-0, C6H6ClNO2S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Celecoxib Impurity 34 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H6ClNO2S |
| Molecular Weight | 191.64 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Celecoxib Standards
- Celecoxib Impurity 35 (CAS 98-64-6)
- Celecoxib Impurity N3 (CAS 877-67-8)
- Celecoxib Impurity 38 (CAS 131774-72-6)
- Celecoxib Impurity 40 (CAS 4392-54-5)
- Celecoxib Impurity 45 (CAS 90824-33-2)
- Celecoxib Impurity N4 (CAS 90829-71-3)
- Celecoxib Impurity 27 (CAS 343853-74-7)
- Celecoxib Impurity 62 (CAS CATO-C4X-104362)
Recommended Standards
- Pyridin-2-ylmethanesulfonyl chloride (CAS 540523-41-9)
- N-Chlorobenzenesulfonamide (CAS 80-16-0)
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- Empagliflozin Impurity 126 (CAS CATO-C4X-1065126)
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