Doxorubicin Dimer Impurity 13 CAS 2755741-04-7
| CAS No. | 2755741-04-7 |
| Molecular Formula | C54H56N2O21 |
| Molecular Weight | 1069.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Doxorubicin Dimer Impurity 13 (C54H56N2O21) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Doxorubicin Dimer Impurity 13 (CAS 2755741-04-7, C54H56N2O21) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C54H56N2O21 |
| Molecular Weight | 1069.02 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 28.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2002 |
| Nitrogen Atoms | 2 |
Related Doxorubicin Standards
- Doxorubicin Impurity 19 (CAS CATO-C4X-203319)
- Doxorubicin Dimer Impurity 23 (CAS 201278-93-5)
- Doxorubicin Impurity 22 (CAS CATO-C4X-203322)
- Doxorubicin Impurity 30 (CAS CATO-C4X-203330)
- Doxorubicin-hydrazone-caproyl-maleimide (CAS 151038-96-9)
- Doxorubicin Impurity 27 (CAS CATO-C4X-203327)
- Doxorubicin Impurity N19 (CAS 106401-68-7)
- Doxorubicin Impurity 25 (CAS CATO-C4X-203325)
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