Lenvatinib Impurity N1 CAS 28443-57-4
| CAS No. | 28443-57-4 |
| Molecular Formula | C6H5Cl2NO |
| Molecular Weight | 178.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Lenvatinib Impurity N1 (CAS 28443-57-4) is a certified pharmaceutical impurity reference standard with the molecular formula C6H5Cl2NO and a molecular weight of 178.02 g/mol.
The molecular framework of Lenvatinib Impurity N1 (C6H5Cl2NO) is characterized by an amide group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO manufactures Lenvatinib Impurity N1 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C6H5Cl2NO |
| Molecular Weight | 178.02 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1965 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Lenvatinib Standards
- Lenvatinib Impurity 70 (CAS 56962-03-9)
- Lenvatinib Impurity 129 (CAS 26271-75-0)
- Lenvatinib Impurity 10 (CAS 97480-55-2)
- Lenvatinib Impurity 112 (CAS 82121-05-9)
- Lenvatinib Impurity 183 (CAS 72793-38-5)
- Lenvatinib Impurity 102 (CAS 15568-85-1)
- Lenvatinib Impurity 142 (CAS 1069122-99-1)
- Lenvatinib Impurity 98 (CAS CATO-C4X-114098)
Recommended Standards
- 4-Amino-2,3-dichlorophenol (CAS 39183-17-0)
- 4-Amino-2,5-dichlorophenol (CAS 50392-39-7)
- N-(2,3-dichlorophenyl)hydroxylamine (CAS 43192-06-9)
- benzothiophen-7-ylboronic acid (CAS 628692-17-1)
- Capivasertib Impurity 44 (CAS CATO-C4X-331244)
- Betacarotene impurity 7 (CAS CATO-C4X-28157)
- Ritonavir EP Impurity N (CAS 202816-62-4)
- 3-(methylsulfanyl)-1-{[1,2,4]triazolo[4,3-a]pyridin-3-yl}propan-1-amine dihydrochloride (CAS 1049693-70-0)
- 8-(Methylsulfonyl)-1-oxa-4-thia-8-azaspiro[4.5]decane (CAS 1351601-18-7)
- (Rp)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl (2-hydroxyphenyl)(2-phenylpropan-2-yl)phosphinate (CAS 1592980-37-4)
- (E)-3-(2-Acetylanilino)-1-(4-phenoxyphenyl)-2-propen-1-one (CAS 478064-87-8)
- 2-Ethylphenothiazine (CAS 61852-27-5)
- tert-butyl 6-hydroxy-6-methyl-1,4-oxazepane-4-carboxylate (CAS 1801455-05-9)
- endo-Ser39-Tirzepatide (CAS CATO-CPTD788935)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com