Lenvatinib Impurity 129 CAS 26271-75-0
| CAS No. | 26271-75-0 |
| Molecular Formula | C6H5Cl2NO |
| Molecular Weight | 178.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Lenvatinib Impurity 129 (CAS 26271-75-0) is a certified pharmaceutical impurity reference standard with the molecular formula C6H5Cl2NO and a molecular weight of 178.02 g/mol.
Based on its molecular formula C6H5Cl2NO, Lenvatinib Impurity 129 contains an amide group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 178.02 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H5Cl2NO |
| Molecular Weight | 178.02 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Lenvatinib Standards
- Lenvatinib Impurity 70 (CAS 56962-03-9)
- Lenvatinib Impurity N1 (CAS 28443-57-4)
- Lenvatinib Impurity 10 (CAS 97480-55-2)
- Lenvatinib Impurity 112 (CAS 82121-05-9)
- Lenvatinib Impurity 183 (CAS 72793-38-5)
- Lenvatinib Impurity 102 (CAS 15568-85-1)
- Lenvatinib Impurity 142 (CAS 1069122-99-1)
- Lenvatinib Impurity 98 (CAS CATO-C4X-114098)
Recommended Standards
- O-(3,5-Dichlorophenyl)hydroxylamine (CAS 99907-90-1)
- Resmetirom impurity 134 (CAS 28165-63-1)
- O-(3,4-dichlorophenyl)hydroxylamine (CAS 99907-89-8)
- 4-Amino-2,6-dichlorophenol (CAS 5930-28-9)
- Edoxaban impurity 130 (CAS CATO-C4X-1063130)
- Tofacitinib Impurity 234 (CAS CATO-C4X-1079234)
- Apalutamide Impurity 21 (CAS CATO-C4X-274921)
- Tocopherol impurity 40 (CAS CATO-C4X-119540)
- 28325-56-6 IVHD-valtrate (CAS 28325-56-6)
- 2-Pyridinecarboxylic acid, 3-amino-6-chloro-, hydrochloride (1:2) (CAS 866775-04-4)
- (4-Bromophenyl)(2-methoxyphenyl)methanone (CAS 27428-65-5)
- 5-(Isoxazol-5-yl)-2-methylthiophene-3-sulfonyl chloride (CAS 1282484-31-4)
- Fichtelite (CAS 2221-95-6)
- Myristoyl Pentapeptide -4 acetate (CAS 959610-30-1(free base))
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