Alprazolam CAS 28981-97-7
| CAS No. | 28981-97-7 |
| Molecular Formula | C17H13ClN4 |
| Molecular Weight | 308.76 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Alprazolam.
Alprazolam (CAS 28981-97-7), molecular formula C17H13ClN4 and molecular weight 308.76 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, Alprazolam (C17H13ClN4) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 308.76 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Alprazolam meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H13ClN4 |
| Molecular Weight | 308.76 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 1000μg/mL in Methanol |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1965 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Alprazolam Standards
- Alprazolam EP Impurity G (CAS 448950-89-8)
- Alprazolam Impurity 2 (CAS 4016-85-7)
- Alprazolam impurity 24 (CAS CATO-C4X-146024)
- Alprazolam impurity 25 (CAS CATO-C4X-146025)
- Alprazolam Impurity 26 (CAS CATO-C4X-146026)
- Alprazolam impurity 27 (CAS CATO-C4X-146027)
- Alprazolam-D5 (CAS 125229-61-0)
- Alprazolam-D5 (1.0 mg/mL in Methanol) (CAS 1286073-82-2)
Recommended Standards
- Gefapixant Impurity 6 (CAS CATO-C4X-28496)
- 4-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]-3-N-ethyl-1H-pyrazole-3,5-diamine (CAS 1188305-15-8)
- 2,6,10,14-Tetramethylpentadecane-d40 (CAS 16416-35-6)
- Ziprasidone Impurity 71 (CAS CATO-C4X-124071)
- 5-methyl-N-(piperidin-4-yl)pyridin-2-amine hydrochloride (CAS 1185320-00-6)
- 2-[3-(propan-2-yl)-4H-1,2,4-triazol-4-yl]ethan-1-amine dihydrochloride (CAS 1333954-67-8)
- (S)-2-Amino-N-cyclopropyl-3-methyl-N-(((S)-1-methylpyrrolidin-2-yl)methyl)butanamide (CAS 1401667-44-4)
- 2-(Isopropylamino)-2-methyl-4-(1h-1,2,4-triazol-1-yl)butanamide (CAS 1250776-13-6)
- 5-Bromo-4-methylisoquinoline (CAS 651310-24-6)
- 5-(4-Bromobenzyl)furan-2-carboxylic acid (CAS 1399663-94-5)
- 5,6,7,8-Tetrahydronaphthalen-2-yl(thiophen-2-yl)methanamine (CAS 875163-67-0)
- N-(5-(Methoxymethyl)-1,3,4-thiadiazol-2-yl)benzamide (CAS 524676-36-6)
- (7-Amino-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)(5-methylfuran-2-yl)methanone (CAS 886494-34-4)
- Peptide 46 (H-4054.0500) (CAS 192122-40-0)
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