Alprazolam Impurity 2 CAS 4016-85-7
| CAS No. | 4016-85-7 |
| Molecular Formula | C15H11Cl2NO2 |
| Molecular Weight | 308.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Alprazolam Impurity 2 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Alprazolam Impurity 2 (CAS 4016-85-7, C15H11Cl2NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Alprazolam Impurity 2 (C15H11Cl2NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C15H11Cl2NO2 |
| Molecular Weight | 308.16 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Alprazolam Standards
- Alprazolam impurity 24 (CAS CATO-C4X-146024)
- Alprazolam impurity 25 (CAS CATO-C4X-146025)
- Alprazolam Impurity 26 (CAS CATO-C4X-146026)
- Alprazolam impurity 27 (CAS CATO-C4X-146027)
- Alprazolam EP Impurity G (CAS 448950-89-8)
- Alprazolam (CAS 28981-97-7)
- Alprazolam-D5 (CAS 125229-61-0)
- Alprazolam-D5 (1.0 mg/mL in Methanol) (CAS 1286073-82-2)
Recommended Standards
- N,N'-(1,3,4-Thiadiazole-2,5-diyl)bis(2,2,2-trifluoroacetamide) (CAS 61785-06-6)
- N'-(4-Chlorophenyl)-2-oxo-2-(phenylamino)acetohydrazonoyl chloride (CAS 33101-97-2)
- N-(4-Chloro-2-(3-chlorobenzoyl)phenyl)acetamide (CAS 34999-45-6)
- N-(4-acetylphenyl)-3,4-dichlorobenzamide (CAS 5246-14-0)
- Prasugrel Impurity 22 (CAS 204205-33-4)
- Tivozanib Impurity 6 (CAS CATO-C4X-34006)
- Stigmasterol Impurity 4 (CAS 7212-91-1)
- n,n'-Dimethylisoxazole-4-carboximidamide (CAS 940000-15-7)
- 5'-Fluoro-2'-hydroxypropiophenone (CAS 443-09-4)
- Pitavastatin Impurity 124 (CAS 1422058-52-3)
- Ozanimod impurity 36 (CAS 1306760-60-0)
- (1-Ethyl-3,5-dimethyl-1h-pyrazol-4-yl)methanol (CAS 90152-72-0)
- Dimethyl-1,1,1-d3-amine (gas) (CAS 20786-94-1)
- [β-Asp]9-Semaglutide (CAS CATO-CPTD788605)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com