Alprazolam EP Impurity G CAS 448950-89-8
| CAS No. | 448950-89-8 |
| Molecular Formula | C17H13ClN4 |
| Molecular Weight | 308.76 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Alprazolam EP Impurity G under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Alprazolam EP Impurity G (CAS 448950-89-8, C17H13ClN4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Alprazolam EP Impurity G (C17H13ClN4) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C17H13ClN4 |
| Molecular Weight | 308.76 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Alprazolam Standards
- Alprazolam (CAS 28981-97-7)
- Alprazolam Impurity 2 (CAS 4016-85-7)
- Alprazolam impurity 24 (CAS CATO-C4X-146024)
- Alprazolam impurity 25 (CAS CATO-C4X-146025)
- Alprazolam Impurity 26 (CAS CATO-C4X-146026)
- Alprazolam impurity 27 (CAS CATO-C4X-146027)
- Alprazolam-D5 (CAS 125229-61-0)
- Alprazolam-D5 (1.0 mg/mL in Methanol) (CAS 1286073-82-2)
Recommended Standards
- Ziprasidone Impurity 71 (CAS CATO-C4X-124071)
- Gefapixant Impurity 6 (CAS CATO-C4X-28496)
- (4-chlorophenyl)(4-phenoxyphenyl)methanone (CAS CATO-C3D-262926)
- 4124-31-6 Trichloroacetic anhydride Acetic acid, 2,2,2-trichloro-, 1,1'-anhydride Acetic acid, trichloro-, anhydride EINECS 223-925-3 (CAS 4124-31-6)
- Nitrofurantoin Impurity 2 (CAS 777-34-4)
- Antipyrine Impurity 3 (CAS 1430813-66-3)
- Lefamulinum Impurity 29 (CAS CATO-C4X-304729)
- 5-((2-Bromobenzyl)thio)-1h-1,2,4-triazole (CAS 1001604-63-2)
- 1-Benzyl-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline-6-carbaldehyde (CAS 80162-60-3)
- 2-((1-Benzylpiperidin-3-yl)(isopropyl)amino)ethanol (CAS 1353965-67-9)
- Methyl 3-{1-[(4-chlorophenyl)methyl]-6-oxo-1,6-dihydropyridine-3-amido}thiophene-2-carboxylate (CAS 339008-57-0)
- methyl 6-(4-methoxyphenyl)-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate (CAS 1011371-10-0)
- 6-Chloro-2-(4-methoxyphenyl)-3-methylquinoline-4-carboxylic acid (CAS 932796-35-5)
- Semaglutide impurity 236 (CAS CATO-C4X-2226236)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com