Alprazolam Impurity 26 CAS CATO-C4X-146026
| CAS No. | CATO-C4X-146026 |
| Molecular Formula | C15H11Cl2NO2 |
| Molecular Weight | 308.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Alprazolam Impurity 26 (CAS CATO-C4X-146026, C15H11Cl2NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Alprazolam Impurity 26 (C15H11Cl2NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H11Cl2NO2 |
| Molecular Weight | 308.16 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Alprazolam Standards
- Alprazolam Impurity 2 (CAS 4016-85-7)
- Alprazolam impurity 24 (CAS CATO-C4X-146024)
- Alprazolam impurity 25 (CAS CATO-C4X-146025)
- Alprazolam impurity 27 (CAS CATO-C4X-146027)
- Alprazolam EP Impurity G (CAS 448950-89-8)
- Alprazolam (CAS 28981-97-7)
- Alprazolam-D5 (CAS 125229-61-0)
- Alprazolam-D5 (1.0 mg/mL in Methanol) (CAS 1286073-82-2)
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- Methyl 2-(3-chlorobenzamido)-4,5-dimethylthiophene-3-carboxylate (CAS 447409-05-4)
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