Ixazomib Impurity 71 CAS 2920604-29-9
| CAS No. | 2920604-29-9 |
| Molecular Formula | C22H30BCl2NO3 |
| Molecular Weight | 438.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Ixazomib Impurity 71 (CAS 2920604-29-9, C22H30BCl2NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Ixazomib Impurity 71 (C22H30BCl2NO3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C22H30BCl2NO3 |
| Molecular Weight | 438.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2004 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Ixazomib Standards
- Ixazomib Impurity 75 (CAS CATO-C4X-126775)
- Ixazomib Impurity 20 (CAS CATO-C4X-126720)
- Ixazomib Impurity 35 (CAS CATO-C4X-126735)
- Ixazomib Impurity 86 (CAS CATO-C4X-126786)
- Ixazomib Impurity 87 (CAS CATO-C4X-126787)
- Ixazomib Impurity 46 (CAS CATO-C4X-126746)
- Ixazomib Impurity 47 (CAS CATO-C4X-126747)
- Ixazomib Impurity 48 (CAS CATO-C4X-126748)
Recommended Standards
- 1,3-Bis(2-(5-bromothiophen-2-yl)ethyl)urea (CAS 2432029-02-0)
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- (E)-6-(2-((4-iodophenyl)amino)vinyl)pyrazolo[1,5-a]pyrido[3,4-e]pyrimidine-3-carbonitrile (CAS 338966-86-2)
- BTO4-2Br (CAS 1973413-17-0)
- Semaglutide impurity 210 (CAS CATO-C4X-2226210)
- Ertugliflozin impurity 3 (CAS 1298086-37-9)
- Carboxyamidotriazole Impurity 3 HCl (CAS CATO-C4X-21593)
- 2-(Ethylsulfonyl)-1-(3-fluorophenyl)ethanone (CAS 1343309-99-8)
- 4-(2-(Trifluoromethyl)phenoxy)benzenesulfonylchloride (CAS 885950-91-4)
- (4-((4-Isopropylphenyl)carbamoyl)phenyl)boronic acid (CAS 913198-22-8)
- 1-(Cyclopropylmethyl)-1H-pyrazole-5-carboxylic acid (CAS 1497772-92-5)
- tert-Butyl 7-methoxy-1H-indazole-1-carboxylate (CAS 1337881-48-7)
- tert-butyl N-[(1S,3R)-3-hydroxycyclopentyl]-N-methyl-carbamate (CAS 2370967-14-7)
- Prolactin-Releasing Peptide (1-31) (rat) (CAS 215510-06-8)
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