Dasatinib impurity 67 CAS 302964-06-3
| CAS No. | 302964-06-3 |
| Molecular Formula | C16H18ClN3O3S |
| Molecular Weight | 367.85 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Dasatinib impurity 67 (CAS 302964-06-3) is a certified pharmaceutical impurity reference standard with the molecular formula C16H18ClN3O3S and a molecular weight of 367.85 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution, Dasatinib impurity 67 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 367.85 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Dasatinib impurity 67 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H18ClN3O3S |
| Molecular Weight | 367.85 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Dasatinib Standards
- Dasatinib Impurity N57 (CAS 1245157-42-9)
- Dasatinib impurity 60 (CAS CATO-C4X-160760)
- Dasatinib Impurity 74 (CAS CATO-C4X-160774)
- Dasatinib Impurity 46 (CAS CATO-C4X-160746)
- Dasatinib Impurity 55 (CAS CATO-C4X-160755)
- Dasatinib Impurity 29 (CAS CATO-C4X-160729)
- Dasatinib Dichloro Impurity (CAS 302964-08-5)
- Dasatinib Impurity 73 (CAS CATO-C4X-160773)
Recommended Standards
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- Ethyl 1-(2-cyano-4-nitrophenyl)piperidine-3-carboxylate (CAS 731793-03-6)
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