Dasatinib Impurity 74 CAS CATO-C4X-160774

Purity 95%In StockPharmacopoeial Impurity Standards
CAS No.CATO-C4X-160774
Molecular FormulaC18H24ClN5O
Molecular Weight361.87 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Dasatinib Impurity 74 CAS CATO-C4X-160774 chemical structure

Description

Dasatinib Impurity 74 (CAS CATO-C4X-160774) is a certified pharmaceutical impurity reference standard with the molecular formula C18H24ClN5O and a molecular weight of 361.87 g/mol.

Dasatinib Impurity 74 (C18H24ClN5O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC18H24ClN5O
Molecular Weight361.87 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor)
Purity95%
StorageStore at 2-8°C, protect from light
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)9.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
Halogen ContentCl-containing
Nitrogen Atoms5

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