(E)-4-((3,4-dichlorobenzyl)oxy)-N'-(3-nitrobenzylidene)benzohydrazide CAS 303987-29-3
| CAS No. | 303987-29-3 |
| Molecular Formula | C21H15Cl2N3O4 |
| Molecular Weight | 444.27 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (E)-4-((3,4-dichlorobenzyl)oxy)-N'-(3-nitrobenzylidene)benzohydrazide.
(E)-4-((3,4-dichlorobenzyl)oxy)-N'-(3-nitrobenzylidene)benzohydrazide (CAS 303987-29-3), molecular formula C21H15Cl2N3O4 and molecular weight 444.27 g/mol, is a CATO reference standard with documented purity and traceability.
(E)-4-((3,4-dichlorobenzyl)oxy)-N'-(3-nitrobenzylidene)benzohydrazide (C21H15Cl2N3O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (E)-4-((3,4-dichlorobenzyl)oxy)-N'-(3-nitrobenzylidene)benzohydrazide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H15Cl2N3O4 |
| Molecular Weight | 444.27 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related E Standards
- 1-Benzyl-3-(5-((2,4-dichlorobenzyl)thio)-1,3,4-oxadiazol-2-yl)pyridin-2(1H)-one (CAS 242472-23-7)
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- 1-(3,4-Dichlorobenzyl)-5-(4-(pyridin-2-yl)piperazine-1-carbonyl)pyridin-2(1H)-one (CAS 860649-40-7)
- 1-(3,4-Dichlorobenzyl)-4-(4-fluorobenzoyl)-3-methyl-3,4-dihydroquinoxalin-2(1H)-one (CAS 317833-40-2)
- 1-(3,4-Dichlorobenzyl)-3-((2,6-dichlorobenzyl)oxy)-2-methylpyridin-4(1H)-one (CAS 338965-46-1)
- 4-(2,4-Dichlorobenzyl)-N-(4-fluorophenyl)-3-oxo-3,4-dihydroquinoxaline-2-carboxamide (CAS 338419-33-3)
Recommended Standards
- tert-Butyl-(R)-3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate, 97% (CAS 1276110-38-3)
- 4-(3-(2,6-Dichlorophenyl)-5-methylisoxazole-4-carbonyl)-N-(furan-2-ylmethyl)-1H-pyrrole-2-carboxamide (CAS 866049-52-7)
- methyl (S)-(1-((4-(3-iodo-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate (CAS 1269440-60-9)
- Ethyl 3-[2-(2,4-dichlorobenzoyloxy)ethoxy]-5-[(E)-[(dimethylamino)methylidene]amino]-1,2-oxazole-4-carboxylate (CAS 303997-07-1)
- Ethyl (4-aminopiperazin-1-yl)carbamate (CAS 803633-59-2)
- 2-Chloro-4-{[(trifluoromethyl)sulfonyl]amino}benzoic acid (CAS 716361-56-7)
- tert-Butyl 3-(methoxymethyl)piperidine-3-carboxylate (CAS 2137647-95-9)
- (3R,4S,5S,6R)-2-(Dodecyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (CAS 27836-64-2)
- 4,4'-Difluoro-[1,1'-biphenyl]-3,3',5,5'-tetracarboxylic acid (CAS 1628901-94-9)
- 2-Chloro-4-(tert-pentyl)phenol (CAS 5323-65-9)
- Aztreonam Impurity 33 (CAS CATO-C4X-152233)
- Arborinine (CAS 5489-57-6)
- Torasemide Impurity 53 (CAS 69777-53-3)
- Liraglutide(14-22)TFA Salt (CAS CATO-C4X-199212)
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