Levothyroxine Impurity N90 CAS 30804-52-5
| CAS No. | 30804-52-5 |
| Molecular Formula | C19H17I4NO5 |
| Molecular Weight | 846.96 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Levothyroxine Impurity N90 (CAS 30804-52-5), a pharmacopoeial impurity reference standard (molecular formula C19H17I4NO5, MW 846.96 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C19H17I4NO5, Levothyroxine Impurity N90 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, iodine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 846.96 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Levothyroxine Impurity N90 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H17I4NO5 |
| Molecular Weight | 846.96 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1965 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 1 |
Related Levothyroxine Standards
- Levothyroxine sulfate (CAS 77074-49-8)
- Levothyroxine Impurity 4 (CAS 910907-23-2)
- Levothyroxine N-Acetyl Impurity (CAS 26041-51-0)
- Levothyroxine Impurity 54 (CAS CATO-C4X-167854)
- Levothyroxine Ethyl Ester (CAS 76353-71-4)
- Levothyroxine Impurity 27 (CAS 671235-41-9)
- Levothyroxine Impurity 30 (CAS 107849-54-7)
- Levothyroxine impurity 47 (CAS CATO-C4X-167847)
Recommended Standards
- Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 (CAS 121822-32-0)
- 25-O-desacetyl-23-Acetyl-Rifabutin (Possibly a mixture with API) (CAS 1242076-43-2)
- Tricyclohexylphosphine[2,4-dihydro-2,4,5-triphenyl-3H-1,2,4-triazol-3-ylidene][2-thienylmethylene]ruthenium(II) dichloride (CAS 1190427-51-0)
- Rifabutin Impurity 12 (14-epi-Rifabutin) (CAS CATO-C4X-251212)
- Cefetamet Impurity 4 (CAS CATO-C4X-12874)
- Degarelix Impurity 3 (CAS 2648486-37-5)
- Nintedanib Impurity 21 (CAS CATO-C4X-181421)
- (R)-2-Bromo-1-(3-cyclopropyl-7-fluoro-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)ethan-1-one (CAS 2379411-64-8)
- 2-Bromo-3-methoxyquinoline (CAS 128998-00-5)
- 2-((4-Fluorophenyl)carbamoyl)benzoic acid (CAS 19336-77-7)
- Methyl 3-amino-3-(2,4-dimethoxyphenyl)propanoate (CAS 1038323-43-1)
- Agomelatine Impurity 9 HCI (CAS CATO-C4X-1132164)
- tert-butyl N-[(tert-butoxy)carbonyl]-N-(4-oxobutyl)carbamate (CAS 177899-21-7)
- (Des-His1,Glu?)-Glucagon (1-29) amide (human, rat, porcine) (CAS 110084-95-2)
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