Lapatinib Impurity 9 CAS 1393175-04-6
| CAS No. | 1393175-04-6 |
| Molecular Formula | C21H14ClFIN3O |
| Molecular Weight | 505.71 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Lapatinib Impurity 9 (CAS 1393175-04-6) is a certified pharmaceutical impurity reference standard with the molecular formula C21H14ClFIN3O and a molecular weight of 505.71 g/mol.
Based on its molecular formula C21H14ClFIN3O, Lapatinib Impurity 9 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine/iodine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 505.71 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Lapatinib Impurity 9 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H14ClFIN3O |
| Molecular Weight | 505.71 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl/I-containing |
| Nitrogen Atoms | 3 |
Related Lapatinib Standards
- Lapatinib Impurity 25 (CAS 231278-20-9)
- Lapatinib Impurity 7 (CAS 320337-46-0)
- Lapatinib Impurity 17 (CAS 231278-05-0)
- Lapatinib Impurity 19 (CAS 320337-48-2)
- Lapatinib Impurity 14 (CAS 697299-82-4)
- Lapatinib Impurity 10 (CAS 231278-84-5)
- Lapatinib Impurity 26 (CAS CATO-C4X-119126)
- Lapatinib Impurity 37 (CAS 1268997-70-1)
Recommended Standards
- Lefamulinum Impurity 14 (CAS CATO-C4X-304714)
- Elobixibat Impurity 43 (CAS CATO-C4X-283843)
- Lefamulinum Impurity 31 (CAS CATO-C4X-304731)
- Bilastine Impurity 60 (CAS 2699147-41-4)
- Atrasentan Impurity 7 (CAS 178608-09-8)
- Oclacitinib impurity 28 (CAS CATO-C4X-301828)
- Ritonavir Impurity 45 (CAS 1010809-50-3)
- tert-Butyl n-(4-chlorophenyl)-n-methylcarbamate (CAS 693803-49-5)
- 3-(1-Cyclopentyl-1H-pyrazol-5-yl)piperidine (CAS 1437432-02-4)
- 2-((5-Nitrothiazol-2-yl)amino)-2-oxoacetic acid (CAS 1448075-11-3)
- 4-[(4-Boc-1-piperazinyl)methyl]benzoic Acid (CAS 479353-63-4)
- Methyl 2-amino-4-isopropylbenzoate (CAS 204850-17-9)
- 3-Bromo-3-piperidinomethyl benzophenone (CAS 898792-90-0)
- ([13C6]Leu14)-Glucagon (1-29) (human, rat, porcine) trifluoroacetate salt (CAS 1802078-39-2)
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