Lapatinib Impurity 25 CAS 231278-20-9
| CAS No. | 231278-20-9 |
| Molecular Formula | C21H14ClFIN3O |
| Molecular Weight | 505.71 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Lapatinib Impurity 25 (CAS 231278-20-9, C21H14ClFIN3O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C21H14ClFIN3O, Lapatinib Impurity 25 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine/iodine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 505.71 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Lapatinib Impurity 25 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H14ClFIN3O |
| Molecular Weight | 505.71 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2023 |
| Halogen Content | F/Cl/I-containing |
| Nitrogen Atoms | 3 |
Related Lapatinib Standards
- Lapatinib Impurity 9 (CAS 1393175-04-6)
- Lapatinib Impurity 7 (CAS 320337-46-0)
- Lapatinib Impurity 17 (CAS 231278-05-0)
- Lapatinib Impurity 19 (CAS 320337-48-2)
- Lapatinib Impurity 14 (CAS 697299-82-4)
- Lapatinib Impurity 10 (CAS 231278-84-5)
- Lapatinib Impurity 26 (CAS CATO-C4X-119126)
- Lapatinib Impurity 37 (CAS 1268997-70-1)
Recommended Standards
- Elobixibat Impurity 43 (CAS CATO-C4X-283843)
- Bilastine Impurity 60 (CAS 2699147-41-4)
- Lefamulinum Impurity 14 (CAS CATO-C4X-304714)
- Dobutamine Impurity 18 (CAS CATO-C4X-129818)
- Ozenoxacin Impurity 43 (CAS CATO-C4X-279643)
- Nifuratel Impurity 22 (CAS CATO-C4X-127222)
- Polydatin Impurity 1 (CAS 3009113-18-9)
- 4-Amino-5-[4-(diethylamino)phenyl]-4H-1,2,4-triazole-3-thiol (CAS 851207-76-6)
- N-(3-Chlorophenyl)-4-(4-cyanophenyl)tetrahydro-1(2H)-pyrazinecarboxamide (CAS 478046-91-2)
- (E)-3-(4-Bromophenyl)-5-(prop-1-en-1-yl)isoxazole (CAS 638163-16-3)
- 4-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-methylhydrazin-1-yl}-6-hydroxy-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyrimidin-2-one (CAS 866051-56-1)
- 4-Iodo-2-methylisoindolin-1-one (CAS 1379313-49-1)
- (2E)-3-{4-[(2-chloro-6-fluorophenyl)methoxy]phenyl}-N-[(4-fluorophenyl)methyl]prop-2-enamide (CAS 477870-76-1)
- Tirzepatide Impurity 1 (CAS 2460751-66-8)
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