Nicorandil Impurity 57 CAS 342018-76-2
| CAS No. | 342018-76-2 |
| Molecular Formula | C8H10N2O2 |
| Molecular Weight | 166.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Nicorandil Impurity 57.
Nicorandil Impurity 57 (CAS 342018-76-2) is a certified pharmaceutical impurity reference standard with the molecular formula C8H10N2O2 and a molecular weight of 166.18 g/mol.
Based on its molecular formula C8H10N2O2, Nicorandil Impurity 57 contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 166.18 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Nicorandil Impurity 57 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H10N2O2 |
| Molecular Weight | 166.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 2 |
Related Nicorandil Standards
- Nicorandil Impurity N1 (CAS 46053-56-9)
- Nicorandil Impurity 17 (CAS 6265-74-3)
- Nicorandil EP Impurity B (CAS 6265-73-2)
- Nicorandil Impurity 47 (CAS 13362-26-0)
- Nicorandil Impurity 26 (CAS 14906-63-9)
- Nicorandil Impurity 43 (CAS 1570-45-2)
- Nicorandil Impurity 13 (CAS 896133-95-2)
- Nicorandil Impurity 28 (CAS CATO-C4X-190728)
Recommended Standards
- Bumetanide Impurity 43 (CAS 6633-36-9)
- Pyridostigmine Bromide EP Impurity A (CAS 51581-32-9)
- N-(3-methoxyphenyl)-N-methylnitrous amide (CAS 18559-18-7)
- Thiamine /Vitamin B1 Impurity 18 (CAS 1886-34-6)
- Fluticasone Impurity 94 (CAS CATO-C4X-165094)
- Fosfomycin Impurity 80 (CAS CATO-C4X-131680)
- Olanzapine EP Impurity A (CAS 138564-59-7)
- N-methoxy-N-methyl-4-morpholinobenzamide (CAS 887576-33-2)
- 7,8-Dichloro-1,2,3,4-tetrahydroquinolin-2-one (CAS 1423032-53-4)
- 4,4'-(Furan-2,5-diyl)bis(N-ethylbenzimidamide) (CAS 199919-01-2)
- 2-(((2-Chlorobenzyl)amino)methyl)-6-methoxyphenol (CAS 1019615-32-7)
- (E)-2-methoxy-4-((4-oxo-3-(1-phenylethyl)-2-thioxothiazolidin-5-ylidene)methyl)phenyl 4-nitrobenzoate (CAS 374617-50-2)
- 3-(trifluoromethyl)-5H,6H,7H,8H-imidazo[1,5-a]pyrazine (CAS 959238-29-0)
- Des-Gln24-Tirzepatide (CAS CATO-CPTD788949)
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