Nicorandil Impurity 13 CAS 896133-95-2
| CAS No. | 896133-95-2 |
| Molecular Formula | C8H10N2O3 |
| Molecular Weight | 182.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Nicorandil Impurity 13 (CAS 896133-95-2, C8H10N2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage, Nicorandil Impurity 13 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 182.18 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H10N2O3 |
| Molecular Weight | 182.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 2 |
Related Nicorandil Standards
- Nicorandil Impurity 28 (CAS CATO-C4X-190728)
- Nicorandil Impurity 38 (CAS CATO-C4X-190738)
- Nicorandil Impurity 39 (CAS CATO-C4X-190739)
- Nicorandil Impurity 26 (CAS 14906-63-9)
- Nicorandil Impurity N1 (CAS 46053-56-9)
- Nicorandil Impurity 17 (CAS 6265-74-3)
- Nicorandil EP Impurity B (CAS 6265-73-2)
- Nicorandil Impurity 47 (CAS 13362-26-0)
Recommended Standards
- Acipimox impurity 21 (CAS CATO-C4X-186621)
- Pentoxifylline Impurity 30 (CAS CATO-C4X-172830)
- Pyridostigmine Impurity 5 (CAS CATO-C4X-26305)
- Allopurinol impurity 22 (CAS CATO-C4X-145822)
- Indacaterol Impurity 48 (CAS 1384189-12-1)
- Betamethasone impurity 60 (CAS CATO-C4X-143760)
- Oseltamivir Impurity 92 (CAS 1151665-78-9)
- 2-(Chloromethyl)-1-cyclopropyl-1H-imidazole hydrochloride (CAS 135207-03-3)
- Esaxerenone Impurity 5 (CAS CATO-C4X-34485)
- 4-Bromo-5-(bromomethyl)-1,2-thiazole (CAS 2092486-98-9)
- 2,5-Dioxopyrrolidin-1-yl 3-(bromomethyl)benzoate (CAS 155863-35-7)
- 6-Bromo-2-[2-(pyridin-4-yl)ethenyl]quinoline-4-carboxylic acid (CAS 926204-88-8)
- Alogliptin Impurity 46 (CAS 1430222-06-2)
- D-Gln24-Tirzepatide (CAS CATO-CPTD788910)
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