5-Chloro-2-fluorophenylboronic acid CAS 352535-83-2
| CAS No. | 352535-83-2 |
| Molecular Formula | C6H5BClFO2 |
| Molecular Weight | 174.37 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 5-Chloro-2-fluorophenylboronic acid is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
5-Chloro-2-fluorophenylboronic acid (CAS 352535-83-2), molecular formula C6H5BClFO2 and molecular weight 174.37 g/mol, is a CATO reference standard with documented purity and traceability.
5-Chloro-2-fluorophenylboronic acid (C6H5BClFO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-Chloro-2-fluorophenylboronic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H5BClFO2 |
| Molecular Weight | 174.37 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 3-Chloro-4-fluorophenylboronic Acid (CAS 144432-85-9)
- 4-Chloro-2-fluorophenylboronic Acid (CAS 160591-91-3)
- (2-Chloro-6-fluorophenyl)boronic acid (CAS 313545-32-3)
- 2-Chloro-3-fluorophenylboronic Acid (CAS 871329-52-1)
- 2-Chloro-5-fluorophenylboronic Acid (CAS 444666-39-1)
- 3-Chloro-2-fluorophenylboronic Acid (CAS 352535-82-1)
- 3-Chloro-5-fluorophenylboronic Acid (CAS 328956-61-2)
- (R)-(3-Chloro-2-hydroxypropyl)phosphonic acid (CAS 221627-94-7)
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