3-Chloro-2-fluorophenylboronic Acid CAS 352535-82-1
| CAS No. | 352535-82-1 |
| Molecular Formula | C6H5BClFO2 |
| Molecular Weight | 174.37 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-Chloro-2-fluorophenylboronic Acid.
3-Chloro-2-fluorophenylboronic Acid (CAS 352535-82-1), molecular formula C6H5BClFO2 and molecular weight 174.37 g/mol, is a CATO reference standard with documented purity and traceability.
3-Chloro-2-fluorophenylboronic Acid (C6H5BClFO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 3-Chloro-2-fluorophenylboronic Acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H5BClFO2 |
| Molecular Weight | 174.37 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 3-Chloro-4-fluorophenylboronic Acid (CAS 144432-85-9)
- 4-Chloro-2-fluorophenylboronic Acid (CAS 160591-91-3)
- (2-Chloro-6-fluorophenyl)boronic acid (CAS 313545-32-3)
- 2-Chloro-3-fluorophenylboronic Acid (CAS 871329-52-1)
- 2-Chloro-5-fluorophenylboronic Acid (CAS 444666-39-1)
- 3-Chloro-5-fluorophenylboronic Acid (CAS 328956-61-2)
- 5-Chloro-2-fluorophenylboronic acid (CAS 352535-83-2)
- (R)-(3-Chloro-2-hydroxypropyl)phosphonic acid (CAS 221627-94-7)
Recommended Standards
- Bromochloronitromethane (CAS 135531-25-8)
- Bromochloroacetic acid-1-<SUP>13</SUP>C (CAS 1173018-43-3)
- 1,1,1,3,3-Pentamethyl-3-vinyldisiloxane (CAS 1438-79-5)
- Hexyl(trimethylsilyl) Ether (CAS 17888-62-9)
- 5-methyl-3-phenylimidazolidine-2,4-dione (CAS 33558-00-8)
- 3-(2-Ethylphenyl)azetidine (CAS 1260683-27-9)
- Benzo[d][1,3]dioxol-5-yl(1-phenethyl-1,4-bipiperidin-3-yl)methanone (CAS 958842-51-8)
- N-(benzo[d][1,3]dioxol-4-ylmethyl)cyclopentanamine (CAS 1156165-37-5)
- 4-Cyclopropoxy-3-isopropylpyridine-2-sulfonamide (CAS 1243286-66-9)
- (1-Benzhydrylazetidin-3-yl) 3-amino-3-imino-propanoate (CAS 116574-09-5)
- 5-Chloro-1-methyl-1H-benzo[d]imidazol-2(3H)-one (CAS 15965-71-6)
- 4-[4-(3,4-Dimethylphenyl)-1-piperazinyl]-4-oxobutanoic acid (CAS 896519-96-3)
- N-(4,5,6,7-Tetrahydro-2H-indazol-5-yl)acetamide (CAS 74197-10-7)
- D-Thr7-Tirzepatide (CAS CATO-CPTD788924)
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