Ticagrelor EP Impurity E CAS 376608-71-8
| CAS No. | 376608-71-8 |
| Molecular Formula | C9H9F2N |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 321.32 g/mol gives Ticagrelor EP Impurity E distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Ticagrelor EP Impurity E (CAS 376608-71-8) is a certified pharmaceutical impurity reference standard with the molecular formula C9H9F2NC8H8O3 and a molecular weight of 321.32 g/mol.
The molecular framework of Ticagrelor EP Impurity E (C9H9F2NC8H8O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Ticagrelor EP Impurity E under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C9H9F2N C8H8O3 |
| Molecular Weight | 321.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Ticagrelor Standards
- Ticagrelor Impurity N40 (CAS 1006376-60-8)
- Ticagrelor Impurity 88 (CAS 1006376-61-9)
- Ticagrelor Impurity 152 (CAS 1006376-62-0)
- Ticagrelor Impurity 121 (CAS 1006614-49-8)
- Ticagrelor impurity 84（trans） (CAS 1006614-51-2)
- Ticagrelor Impurity 113 (CAS 1156575-52-8)
- Ticagrelor impurity 161 (CAS 1157692-93-7)
- Ticagrelor Impurity 168 (CAS 1207276-00-3(free base))
Recommended Standards
- Bacitracin Impurity O (CAS CATO-C4X-155315)
- Linezolid Impurity 112 (CAS CATO-C4X-1073112)
- Pimavanserin Impurity 18 (CAS CATO-C4X-193818)
- 1-(Oxazol-2-yl)ethan-1-amine (CAS 1083396-36-4)
- (S)-2-(Piperidin-2-yl)pyridine dihydrochloride 46041-69-4 (CAS 46041-69-4)
- 3-((2-Chloro-6-fluorobenzyl)oxy)-2-methyl-3'-nitro-4H-[1,2'-bipyridin]-4-one (CAS 303144-66-3)
- 4-(3,5-Dichlorophenyl)-3H-1,2,4-triazole-3,5(4H)-dione (CAS 96567-01-0)
- 3-Oxazol-2-yl-3-oxo-propionic acid tert-butyl ester (CAS 1965309-04-9)
- 2-((1-(5-Chlorothiophen-2-yl)ethyl)amino)butan-1-ol (CAS 1156335-74-8)
- Endo-Gly4-Semaglutide (CAS CATO-C4X-222679)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com