Aprepitant Impurity 30 CAS 172678-47-6
| CAS No. | 172678-47-6 |
| Molecular Formula | C20H18F7NO2 |
| Molecular Weight | 437.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Aprepitant Impurity 30 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Aprepitant Impurity 30 (CAS 172678-47-6) is a certified pharmaceutical impurity reference standard with the molecular formula C20H18F7NO2 and a molecular weight of 437.35 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Aprepitant Impurity 30 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 437.35 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C20H18F7NO2 |
| Molecular Weight | 437.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2006 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Aprepitant Standards
- Aprepitant impurity 01 (CAS 171338-27-5)
- Aprepitant Impurity 41 (CAS CATO-C4X-114141)
- Aprepitant Impurity 43 (CAS CATO-C4X-114143)
- Aprepitant Impurity 22 (CAS 934540-48-4)
- Aprepitant Impurity 48 (CAS 380499-07-0)
- Aprepitant Impurity 23 (CAS 287930-75-0)
- Aprepitant Impurity 24 (CAS 327623-36-9)
- Aprepitant Impurity 25 (CAS CATO-C4X-114125)
Recommended Standards
- Trifloxysulfuron (CAS 145099-21-4)
- (3-((3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-6-(2,3-dichlorophenyl)-5-methylpyrazin-2-yl)methanol (CAS 2172651-73-7)
- Isobutyl 6-(2-bromophenyl)-8-methyl-4-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-7-carboxylate (CAS 609794-68-5)
- 2-(4-Chlorophenyl)-3-((4-(3-chlorophenyl)piperazin-1-yl)methyl)imidazo[1,2-a]pyridine (CAS 861212-34-2)
- Tacrolimus Impurity 38 (CAS CATO-C4X-130038)
- Rasagiline impurity 61 (CAS CATO-C4X-191361)
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- Ethyl 4-amino-5-(4-chloro-3-nitrobenzoyl)-2-((2-(trifluoromethyl)phenyl)amino)thiophene-3-carboxylate (CAS 680212-25-3)
- Dimethyl 2,2'-(benzoylazanediyl)diacetate (CAS 5410-11-7)
- 2-(4-Chlorothiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1040281-84-2)
- (Z)-3-((Benzylamino)methylene)-1-(2,6-dichlorophenyl)indolin-2-one (CAS 172371-92-5)
- 1-[1,1'-biphenyl]-4-yl-1-butanone (CAS 13211-01-3)
- Methyl 3-(5,7-dimethyl-4-oxoquinolin-1(4H)-yl)propanoate (CAS 1279202-04-8)
- D-allo-Thr5-Semaglutide (CAS CATO-C4X-2226243)
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