Aprepitant Impurity 22 CAS 934540-48-4
| CAS No. | 934540-48-4 |
| Molecular Formula | C20H16F7NO2 |
| Molecular Weight | 435.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Aprepitant Impurity 22 (CAS 934540-48-4), a pharmacopoeial impurity reference standard (molecular formula C20H16F7NO2, MW 435.34 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Aprepitant Impurity 22 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 435.34 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Aprepitant Impurity 22 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H16F7NO2 |
| Molecular Weight | 435.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Aprepitant Standards
- Aprepitant Impurity 48 (CAS 380499-07-0)
- Aprepitant impurity 01 (CAS 171338-27-5)
- Aprepitant Impurity 41 (CAS CATO-C4X-114141)
- Aprepitant Impurity 43 (CAS CATO-C4X-114143)
- Aprepitant Impurity 30 (CAS 172678-47-6)
- Aprepitant Impurity 23 (CAS 287930-75-0)
- Aprepitant Impurity 24 (CAS 327623-36-9)
- Aprepitant Impurity 25 (CAS CATO-C4X-114125)
Recommended Standards
- 5-((4-Bromophenyl)thio)-1,3-diphenyl-1H-pyrazole-4-carbaldehyde (CAS 956183-52-1)
- 2-[4-(4-Bromobenzenesulfonyl)piperazin-1-yl]-4,6-dimethylpyridine-3-carbonitrile (CAS 478081-74-2)
- tert-Butyldimethyl[(tributylstannyl)methoxy]silane (CAS 123061-64-3)
- 2-((5-(2-Bromophenyl)-1,3,4-oxadiazol-2-yl)thio)-N-(1-cyanocyclohexyl)propanamide (CAS 875161-01-6)
- Pemafibrate Impurity 8 (CAS CATO-C4X-29038)
- Bromocriptine EP Impurity D (CAS 478-83-1)
- Perospirone Impurity 53 (CAS CATO-C4X-245853)
- 898791-06-5 (3-Chloro-5-fluorophenyl)(cyclobutyl)methanone DTXSID40642544 (CAS 898791-06-5)
- Pranlukast Impurity 3 (CAS 70977-72-9)
- 3-Fluoro-2-hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile (CAS 2764860-84-4)
- 6-(Trifluoromethoxy)-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-amine (CAS 1261731-43-4)
- 4-Ethyl-3-ethynylpyridin-2-amine (CAS 1393560-86-5)
- (S)-N-Benzylidene-1-methoxy-3-phenylpropan-2-amine (CAS 153827-81-7)
- Semaglutide Impurity 3 (CAS CATO-C4X-22263)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com