Aprepitant impurity 01 CAS 171338-27-5
| CAS No. | 171338-27-5 |
| Molecular Formula | C20H18F7NO2 |
| Molecular Weight | 437.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Aprepitant impurity 01 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Aprepitant impurity 01 (CAS 171338-27-5, C20H18F7NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C20H18F7NO2, Aprepitant impurity 01 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 437.35 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Aprepitant impurity 01 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H18F7NO2 |
| Molecular Weight | 437.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2005 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Aprepitant Standards
- Aprepitant Impurity 41 (CAS CATO-C4X-114141)
- Aprepitant Impurity 43 (CAS CATO-C4X-114143)
- Aprepitant Impurity 30 (CAS 172678-47-6)
- Aprepitant Impurity 22 (CAS 934540-48-4)
- Aprepitant Impurity 48 (CAS 380499-07-0)
- Aprepitant Impurity 23 (CAS 287930-75-0)
- Aprepitant Impurity 24 (CAS 327623-36-9)
- Aprepitant Impurity 25 (CAS CATO-C4X-114125)
Recommended Standards
- 2-(R)-[1-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy]-3-(S)-fluorophenylmorpholine-d2[Aprepitant-M2-d2] (CAS 1217645-68-5)
- 2-((6-Bromo-3-ethyl-4-oxo-3,4-dihydroquinazolin-2-yl)thio)-N-(2-cyano-3-methylbutan-2-yl)acetamide (CAS 786726-44-1)
- Pentafluorophenyl 2-(morpholin-4-ylsulphonyl)benzoate (CAS 950603-27-7)
- 3-(azepane-1-sulfonyl)-N-(3-bromophenyl)benzamide (CAS 420831-40-9)
- Lifitegrast Impurity 90 (CAS CATO-C4X-240990)
- Lomustine Impurity 3 (CAS CATO-C4X-22763)
- Risperidone EP Impurity C (CAS 130049-85-3)
- Isavuconazole Impurity 50 (CAS CATO-C4X-123650)
- (3-Bromo-5-chlorophenyl)pentafluoro-l6-sulfane (CAS 2514941-99-0)
- 3-Azaspiro[5.5]undecan-3-amine hydrochloride (CAS 1269455-75-5)
- 1-(1H-Imidazol-2-yl)ethanol (CAS 22098-61-9)
- 4-(2-(Chloromethyl)-6-hydroxypyrimidin-4-yl)-1-isopropylpyrrolidin-2-one (CAS 1713589-45-7)
- 1-Benzyl-4-methyl-3-piperidinamine (CAS 1039738-27-6)
- Acetyl tetrapeptide-3 (CAS 827306-88-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com