Verapamil Impurity 22 CAS 38176-02-2
| CAS No. | 38176-02-2 |
| Molecular Formula | C27H38N2O4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 491.07 g/mol gives Verapamil Impurity 22 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Verapamil Impurity 22 (CAS 38176-02-2, C27H38N2O4HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Verapamil Impurity 22 (C27H38N2O4HCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H38N2O4 HCl |
| Molecular Weight | 491.07 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Verapamil Standards
- Verapamil Impurity N1 (CAS 102201-30-9)
- Verapamil Impurity 38 (CAS 114847-42-6)
- Verapamil D6 HCl (CAS 1185032-80-7)
- Verapamil-d7 Hydrochloride (CAS 1188265-55-5)
- Verapamil EP Impurity G (CAS 120-14-9)
- Verapamil EP Impurity J-D7 HCl (CAS 1216413-74-9)
- Verapamil EP Impurity B HCl (CAS 13078-76-7)
- (S)-(-)-Verapamil-d6 Hydrochloride (CAS 1329611-24-6)
Recommended Standards
- Levetiracetam Impurity 5 (CAS 358629-51-3)
- Terlipressin Impurity 20 X TFA Salt (CAS CATO-C4X-219320)
- Cabozantinib Impurity 14 (CAS CATO-C4X-201814)
- Methyl 2-(4-fluoro-2-methylphenyl)-2-((2,2,2-trifluoroethyl)amino)acetate (CAS 1457920-56-7)
- (5-((Cyclopropylamino)methyl)thiophen-2-yl)boronic acid (CAS 919347-10-7)
- 4-(1h-Pyrazol-3-yl)phenol (CAS 68535-53-5)
- (4S)-tert-Butyl 3-hydroxy-4-phenylpyrrolidine-1-carboxylate (CAS 1957130-61-8)
- 3-Methyl-1H-pyrazolo[3,4-d]pyrimidin-6-amine (CAS 1330755-87-7)
- 3-Iodo-4-isobutyramidobenzoic acid (CAS 1131614-34-0)
- Peptide 438 (CAS CATO-CPTD788438)
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