(11β)-9-Fluoro-11,17-dihydroxy-21-[(methylsulfonyl)oxy]pregna-1,4-diene-3,20-dione CAS 382-66-1
| CAS No. | 382-66-1 |
| Molecular Formula | C22H29FO7S |
| Molecular Weight | 456.52 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (11β)-9-Fluoro-11,17-dihydroxy-21-[(methylsulfonyl)oxy]pregna-1,4-diene-3,20-dione.
(11β)-9-Fluoro-11,17-dihydroxy-21-[(methylsulfonyl)oxy]pregna-1,4-diene-3,20-dione (CAS 382-66-1), molecular formula C22H29FO7S and molecular weight 456.52 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a flavonoid core, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution, (11β)-9-Fluoro-11,17-dihydroxy-21-[(methylsulfonyl)oxy]pregna-1,4-diene-3,20-dione is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 456.52 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H29FO7S |
| Molecular Weight | 456.52 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Fluoro Standards
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Recommended Standards
- 1-(Diphenylmethylene)-2-(triphenylphosphoranylidene)hydrazine (CAS 1109-01-9)
- 1-Benzyl-2-imino-10-methyl-3-(phenylsulfonyl)-1H-dipyrido[1,2-a:2',3'-d]pyrimidin-5(2H)-one (CAS 370868-72-7)
- Etrasimod Impurity 41 (CAS 2863532-92-5)
- 1-Benzyl-2-imino-8-methyl-3-(phenylsulfonyl)-1,2-dihydro-5H-dipyrido[1,2-a:2',3'-d]pyrimidin-5-one (CAS 606950-50-9)
- Bis(oxiran-2-ylmethyl) terephthalate (CAS 7195-44-0)
- 1-(2-Fluorophenyl)-4-(3-isopropyl-1,2,4-oxadiazol-5-yl)pyrrolidin-2-one (CAS 1172520-68-1)
- 4-((3-Bromobenzyl)oxy)-1,2-dimethylbenzene (CAS 1309933-02-5)
- 1-Bromo-2-ethylbenzene (CAS 1973-22-4)
- BOC-(RS)-3-amino-3-(2-naphthyl)-propionic acid (CAS 268542-15-0)
- tert-Butyl 4-((trimethylsilyl)ethynyl)-1h-pyrazole-1-carboxylate (CAS 1093193-28-2)
- 2-Acetamido-2-deoxy-3-O-(α-L-fucopyranosyl)-D-glucopyranose Pentaacetate (CAS 309263-13-6)
- 2-(3-Bromo-5,6-difluoro-2-methoxyphenyl)acetic acid (CAS 1889215-54-6)
- Ethyl 2,4-Dioxohexanoate (CAS 13246-52-1)
- Acetyl-Tau Peptide (273-284) amide trifluoroacetate salt (CAS 1684399-52-7)
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