Nicergoline EP Impurity A CAS 38536-28-6
| CAS No. | 38536-28-6 |
| Molecular Formula | C24H26ClN3O3 |
| Molecular Weight | 439.93 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Nicergoline EP Impurity A is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Nicergoline EP Impurity A (CAS 38536-28-6) is a certified pharmaceutical impurity reference standard with the molecular formula C24H26ClN3O3 and a molecular weight of 439.93 g/mol.
Nicergoline EP Impurity A (C24H26ClN3O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H26ClN3O3 |
| Molecular Weight | 439.93 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Nicergoline Standards
- Nicergoline EP Impurity G (CAS 57935-65-6)
- Nicergoline Impurity 15 (CAS CATO-C4X-208515)
- Nicergoline EP Impurity B (CAS 35264-46-1)
- Nicergoline EP Impurity E (CAS 57935-66-7)
- Nicergoline EP Impurity H (CAS 192504-81-7)
- Nicergoline (CAS 27848-84-6)
- Nicergoline Impurity 26 (CAS CATO-C4X-208526)
- Nicergoline EP Impurity F (CAS 58001-19-7)
Recommended Standards
- N'-(4-Chlorobenzoyl)-3-cyclohexyl-2-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)propanehydrazide (CAS 338963-31-8)
- MRS 2395 (CAS 491611-55-3)
- (E)-{[4-(4-chlorophenyl)-7-thia-2,5-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(8),3,5-trien-3-yl]methylidene}[(3-fluorophenyl)methoxy]amine (CAS 478041-82-6)
- Palbociclib Impurity 168 (CAS 362658-21-7)
- Atrasentan Impurity 52 (CAS 1059057-00-9)
- Celecoxib Impurity 55 (CAS 64704-17-2)
- Ziprasidone Impurity 20 (CAS 65435-04-3)
- N-[2-(2,6-Dimethylphenoxy)propyl]-2-isopropoxyaniline (CAS 1040683-57-5)
- 2,2-difluorobenzo[d][1,3]dioxol-5-amine (CAS 1544-85-0)
- Ethyl 5-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate (CAS 85614-89-7)
- 2-(2-Ethoxyethoxy)ethyl Acrylate (CAS 7328-17-8)
- Benzyl (4-bromo-2-chlorophenyl)carbamate (CAS 1259064-47-5)
- 3,5-Dimethyl-1-(tetrahydro-2H-pyran-2-yl)pyrazole (CAS 1820650-04-1)
- Myristoyl Pentapeptide-4 (CAS 1392416-25-9)
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