Doxycycline EP Impurity A HCl CAS 41411-66-9
| CAS No. | 41411-66-9 |
| Molecular Formula | C22H24N2O8 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Doxycycline EP Impurity A HCl (CAS 41411-66-9, C22H24N2O8HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Doxycycline EP Impurity A HCl (C22H24N2O8HCl) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Doxycycline EP Impurity A HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H24N2O8 HCl |
| Molecular Weight | 480.90 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Doxycycline Standards
- Doxycycline Hydrochloride (CAS 10592-13-9)
- Doxycycline EP Impurity F (CAS 122861-53-4)
- Doxycycline Monohydrate (CAS 17086-28-1)
- Doxycycline-13CD3 (CAS 1902958-13-7)
- Doxycycline Impurity 20 (CAS 2000233-92-9)
- Doxycycline Hyclate (CAS 24390-14-5)
- Doxycycline-d3 (CAS 2747918-45-0)
- Doxycycline-d3 HCl (CAS 2747918-45-0 (free base))
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- 14378-39-3 (CAS 14378-39-3)
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