Diltiazem EP Impurity E CAS 42399-49-5
| CAS No. | 42399-49-5 |
| Molecular Formula | C16H15NO3S |
| Molecular Weight | 301.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Diltiazem EP Impurity E.
As a process- or degradation-related impurity, Diltiazem EP Impurity E (CAS 42399-49-5, C16H15NO3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Diltiazem EP Impurity E (C16H15NO3S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Diltiazem EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H15NO3S |
| Molecular Weight | 301.36 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1969 |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Diltiazem Standards
- Diltiazem 2-Epimer O-Desacetyl N-Desdimethylaminoethyl Impurity (CAS 132830-17-2)
- Diltiazem Impurity 20 (CAS 132830-16-1)
- Diltiazem Impurity 21 (CAS 42399-51-9)
- Diltiazem Impurity N1 (CAS 42399-48-4)
- Diltiazem Impurity N2 (CAS 42399-50-8)
- Diltiazem Impurity 18 (CAS 131613-02-0)
- Diltiazem Impurity 23 (CAS 119009-50-6)
- Diltiazem Impurity 33 (CAS CATO-C4X-136833)
Recommended Standards
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