Verapamil EP Impurity C(HCl) CAS 51012-67-0
| CAS No. | 51012-67-0 |
| Molecular Formula | C12H19NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Verapamil EP Impurity C(HCl) (CAS 51012-67-0), a pharmacopoeial impurity reference standard (molecular formula C12H19NO2HCl, MW 245.75 g/mol) used for the identification and quantification of trace impurities in APIs.
Verapamil EP Impurity C(HCl) (C12H19NO2HCl) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Verapamil EP Impurity C(HCl) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H19NO2 HCl |
| Molecular Weight | 245.75 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1971 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Verapamil Standards
- Verapamil Impurity N1 (CAS 102201-30-9)
- Verapamil Impurity 38 (CAS 114847-42-6)
- Verapamil D6 HCl (CAS 1185032-80-7)
- Verapamil-d7 Hydrochloride (CAS 1188265-55-5)
- Verapamil EP Impurity G (CAS 120-14-9)
- Verapamil EP Impurity J-D7 HCl (CAS 1216413-74-9)
- Verapamil EP Impurity B HCl (CAS 13078-76-7)
- (S)-(-)-Verapamil-d6 Hydrochloride (CAS 1329611-24-6)
Recommended Standards
- Venetoclax Impurity 103 (CAS CATO-C4X-2495103)
- Cyproheptadine Impurity 10 (CAS 92496-64-5)
- Furazolidone Impurity 9 (CAS CATO-C4X-29019)
- Methyl 7-bromo-1-benzofuran-5-carboxylate (CAS 286836-79-1)
- 3,5-Dimethoxybenzenedecanal (CAS 137786-97-1)
- Clobetasol Propionate EP Impurity D (CAS 25120-99-4)
- 8-Methoxy-3,5-dimethylisochroman-1-one (CAS 24350-99-0)
- 4-[4-(Methylsulfanyl)phenyl]-2-thiophenecarbaldehyde (CAS 893736-88-4)
- (R)-Methyl 5-iodo-2-(pyrrolidin-2-yl)benzoate (CAS 1217615-09-2)
- Angiotensin II Antipeptide (CAS 121379-63-3)
Why CATO?
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