Fluconazole Impurity 11 CAS 51336-94-8
| CAS No. | 51336-94-8 |
| Molecular Formula | C8H5ClF2O |
| Molecular Weight | 190.57 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 190.57 g/mol gives Fluconazole Impurity 11 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Fluconazole Impurity 11 (CAS 51336-94-8) is a certified pharmaceutical impurity reference standard with the molecular formula C8H5ClF2O and a molecular weight of 190.57 g/mol.
Owing to a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system, Fluconazole Impurity 11 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 190.57 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H5ClF2O |
| Molecular Weight | 190.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1971 |
| Halogen Content | F/Cl-containing |
Related Fluconazole Standards
- Fluconazole Impurity 6 (CAS 51336-95-9)
- Fluconazole Impurity 69 (CAS 98414-56-3)
- Fluconazole Impurity 7 (CAS 173837-65-5)
- Fluconazole Impurity 50 (CAS 58905-21-8)
- Fluconazole EP Impurity C (CAS 514222-44-7)
- Fluconazole Impurity 12 (CAS 188416-33-3)
- Fluconazole EP Impurity E (CAS 86404-63-9)
- Fluconazole Impurity 41 (CAS CATO-C4X-101941)
Recommended Standards
- 2,3 - Difluoro - 4 - methylbenzoyl chloride 2,3-Difluoro-4-methyl-benzoyl chloride 2,3-difluoro-p-toluoyl chloride 261763-38-6 benzoyl chloride, 2,3-difluoro-4-methyl- (CAS 261763-38-6)
- Voriconazole Impurity N1 (CAS 929249-84-3)
- ethyl 5-(chloromethyl)-1,2,4-oxadiazole-3-carboxylate (CAS 1009620-97-6)
- 2-Chloro-2,5-difluoroacetophenone (CAS 60468-36-2)
- Urapidil Impurity 104 (CAS CATO-C4X-1924104)
- Amisulpride Impurity 60 (CAS 2876854-07-6)
- Aztreonam impurity 94 (CAS CATO-C4X-152294)
- 5,6-Dimethoxy-1H-benzo[d][1,2,3]triazole (CAS 117891-22-2)
- 1-(2-Allylphenoxy)-3-morpholinopropan-2-ol (CAS 295360-20-2)
- Nitrosobenzene (CAS 586-96-9)
- 7-Benzyl-2,6,8-trichloro-7H-purine (CAS 93702-69-3)
- 3-(4-Fluorophenyl)-5-(4-methylpiperidin-4-yl)-1,2,4-oxadiazole (CAS 1466010-72-9)
- 3-(Trifluoromethoxy)-5,6,7,8-tetrahydro-1,6-naphthyridine (CAS 625099-23-2)
- D-[Asp]9-Semaglutide (CAS CATO-CPTD788631)
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