Fluticasone Impurity 49 CAS CATO-C4X-165049
| CAS No. | CATO-C4X-165049 |
| Molecular Formula | C22H28ClFO5 |
| Molecular Weight | 426.91 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Fluticasone Impurity 49 (CAS CATO-C4X-165049) is a certified pharmaceutical impurity reference standard with the molecular formula C22H28ClFO5 and a molecular weight of 426.91 g/mol.
Based on its molecular formula C22H28ClFO5, Fluticasone Impurity 49 contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 426.91 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H28ClFO5 |
| Molecular Weight | 426.91 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
Related Fluticasone Standards
- Fluticasone Impurity 101 (CAS CATO-C4X-1650101)
- Fluticasone Impurity 68 (CAS 1744-64-5)
- Fluticasone Furoate Impurity 2 (CAS 1355648-15-5)
- Fluticasone Impurity 106 (CAS CATO-C4X-1650106)
- Fluticasone Impurity 111 (CAS 785806-92-0)
- Fluticasone Impurity 112 (CAS CATO-C4X-1650112)
- Fluticasone Impurity 54 (CAS 4571-51-1)
- Fluticasone Impurity 96 (CAS CATO-C4X-165096)
Recommended Standards
- Halometasone impurity 14 (CAS CATO-C4X-144614)
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- Sugammadex sodium Impurity 81 (CAS CATO-C4X-190681)
- Vigabatrin Impurity 10 DiHCl (CAS CATO-C4X-119610)
- Levocetirizine Impurity 48 (CAS CATO-C4X-108348)
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- 5-[(2-Chlorophenyl)sulfanyl]-N-(4-methoxyphenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide (CAS 321553-40-6)
- 2-(Methoxymethoxy)propanehydrazide (CAS 98159-92-3)
- 4-(Aminomethyl)-2-chlorobenzoic acid (CAS 1208507-67-8)
- 4'-Chloro-[1,1'-biphenyl]-4-carboxylic acid (CAS 5748-41-4)
- Pyrimidin-2-yl(thiophen-3-yl)methanamine (CAS 1465849-43-7)
- Copper Peptide ยท2 acetate salt (CAS 130120-57-9)
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