Fosaprepitant Impurity 16 CAS 327623-34-7
| CAS No. | 327623-34-7 |
| Molecular Formula | C21H19F6NO3 |
| Molecular Weight | 447.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 447.37 g/mol gives Fosaprepitant Impurity 16 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Fosaprepitant Impurity 16 (CAS 327623-34-7, C21H19F6NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C21H19F6NO3, Fosaprepitant Impurity 16 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 447.37 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H19F6NO3 |
| Molecular Weight | 447.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fosaprepitant Standards
- Fosaprepitant Impurity 49（Racemate） (CAS CATO-C4X-116849)
- Fosaprepitant Impurity 59 (CAS CATO-C4X-116859)
- Fosaprepitant Impurity 30 (CAS 327623-37-0)
- Fosaprepitant Impurity 37 (CAS CATO-C4X-116837)
- Fosaprepitant Impurity 48 (CAS 1707-92-2)
- Fosaprepitant Impurity 53 (CAS 1254261-32-9)
- Fosaprepitant Impurity 38 (CAS 990-91-0)
- Fosaprepitant Impurity 7 (CAS CATO-C4X-11687)
Recommended Standards
- Aprepitant Impurity 78 (CAS CATO-C4X-114178)
- Aprepitant Impurity 77 (CAS CATO-C4X-114177)
- Aprepitant Impurity 26 (CAS CATO-C4X-114126)
- Flecainide-D4 N-nitroso (CAS 2901085-00-3)
- Olaparib Impurity 95 (CAS CATO-C4X-113595)
- Clopidogrel EP Impurity B HCl (CAS 1396607-35-4)
- Abiraterone Impurity 64 (CAS CATO-C4X-107064)
- 2-Phenyl-4h-furo[3,2-b]pyrrole-5-carboxylic acid (CAS 86345-44-0)
- 2-((2,6-Dimethylquinolin-4-yl)thio)acetic acid (CAS 951625-90-4)
- Methyl 4-{[6-(4-chlorophenyl)-2-oxo-1,2-dihydropyridin-1-yl]methyl}benzoate (CAS 866048-89-7)
- 3-Methyl-1-(1,4,5,6-tetrahydropyrimidin-2-yl)-4,5-dihydro-1H-pyrazol-5-one (CAS 338402-58-7)
- 3,4-Bis(methylamino)cyclobut-3-ene-1,2-dione (CAS 52094-05-0)
- 4-Benzoyl-1-oxa-4-azaspiro[4.5]decane-3-carboxylic acid (CAS 637773-04-7)
- Peptide-GMF (CAS CATO-CPTD788469)
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