Mometasone EP Impurity M CAS 57780-86-6
| CAS No. | 57780-86-6 |
| Molecular Formula | C22H29ClO4 |
| Molecular Weight | 392.92 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 392.92 g/mol gives Mometasone EP Impurity M distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Mometasone EP Impurity M (CAS 57780-86-6), a pharmacopoeial impurity reference standard (molecular formula C22H29ClO4, MW 392.92 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution, Mometasone EP Impurity M is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 392.92 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H29ClO4 |
| Molecular Weight | 392.92 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | Cl-containing |
Related Mometasone Standards
- Mometasone Furoate EP Impurity Q (CAS 83881-08-7)
- Mometasone Furoate Impurity 25 (CAS CATO-C4X-170425)
- Mometasone Furoate EP Impurity K (CAS 4647-20-5)
- Mometasone Impurity 51 (CAS CATO-C4X-170451)
- Mometasone Impurity C13 (CAS 151265-36-0)
- Mometasone Furoate Impurity 24 (CAS CATO-C4X-170424)
- Mometasone Related Compound 4 (CAS 37413-91-5)
- Mometasone Impurity 28 (CAS CATO-C4X-170428)
Recommended Standards
- Desoximetasone Impurity 5 (CAS 4306-57-4)
- N-(3-Chloro-2-methylphenyl)-2-((4-ethyl-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 562829-68-9)
- Betamethasone impurity 65 (CAS CATO-C4X-143765)
- N-(5-Chloro-2-methylphenyl)-2-((4-ethyl-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 562805-11-2)
- Letrozole EP Impurity A (CAS 112809-52-6)
- Varenicline Impurity 14 (CAS CATO-C4X-196214)
- Baloxavir Impurity 4 (CAS CATO-C4X-21084)
- 3-Chloro-4-hydroxy-n-(pyridin-3-ylmethyl)benzamide (CAS 1041525-50-1)
- 3-Methyl-1H-indazole-5,6-diamine (CAS 724767-00-4)
- 3-Methyl-N-(6-methyl-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)benzamide (CAS 313500-20-8)
- 2,6-Dibromo-3-pyridinecarboxylic acid (CAS 55304-85-3)
- 5-(Tetrahydro-2H-pyran-4-yl)pyridin-3-amine (CAS 1259442-70-0)
- Ethyl 4-(dimethylamino)-7-fluoroquinoline-3-carboxylate (CAS 1315344-26-3)
- Peptide 433 (CAS CATO-CPTD788433)
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