Levothyroxine EP Impurity K CAS 5817-39-0
| CAS No. | 5817-39-0 |
| Molecular Formula | C15H12I3NO4 |
| Molecular Weight | 650.97 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Levothyroxine EP Impurity K (CAS 5817-39-0) is a certified pharmaceutical impurity reference standard with the molecular formula C15H12I3NO4 and a molecular weight of 650.97 g/mol.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, iodine substitution, Levothyroxine EP Impurity K is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 650.97 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Levothyroxine EP Impurity K under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C15H12I3NO4 |
| Molecular Weight | 650.97 g/mol |
| Purity | >90% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 1 |
Related Levothyroxine Standards
- Levothyroxine EP Impurity A (CAS 6893-02-3)
- Levothyroxine EP Impurity K (R-Isomer) (CAS 66701-15-3)
- Levothyroxine Impurity 15 (CAS CATO-C4X-167815)
- Levothyroxine Impurity 14 (CAS 3914-31-6)
- Levothyroxine Impurity 17 (CAS 51-26-3)
- Levothyroxine EP Impurity C (CAS 51-24-1)
- Levothyroxine Impurity 16 (CAS 92905-78-7)
- Levothyroxine EP Impurity B (CAS 1628720-66-0)
Recommended Standards
- Liothyronine related impurity, (R)-2-amino (CAS 5714-08-9)
- Mn(III) Protoporphyrin IX chloride (CAS 120389-54-0)
- Uvarimacrophin A (CAS 167425-75-4)
- (Z)-Thiobis(ethane-2,1-diyl) dioleate (CAS 65808-58-4)
- Riociguat Impurity 35 (CAS CATO-C4X-174935)
- Ketorolac Impurity 23 (CAS 141054-42-4)
- Brinzolamide Impurity 11 (CAS CATO-C4X-194011)
- 3-(3-Hydroxyphenyl)propanal (CAS 26172-10-1)
- 4-(2-aminophenoxy)azetidin-2-one (CAS 1909318-85-9)
- 2-(Bromomethyl)-4-methylanisole (CAS 911060-76-9)
- 7,9,9-Trimethyl-1,4-dioxaspiro[4.5]dec-6-en-8-one (CAS 14203-64-6)
- 2-FLUORO-6-METHYLPYRIDINE-5-CARBOXYLIC ACID 2-METHYL-6-FLUORO-3-NICOTINIC ACID 3-PYRIDINECARBOXYLIC ACID, 6-FLUORO-2-METHYL- 6-FLUORO-2-METHYL-3-PYRIDINECARBOXYLIC ACID 6-FLUORO-2-METHYLNICOTINIC ACID 6-FLUORO-2-METHYLPYRIDINE-3-CARBOXYLIC ACID 884494-97-7 ABBYPHARMA AP-15-5904 YF10007 (CAS 884494-97-7)
- 2-(4-Bromo-3-chloro-2-methylphenyl)-1,3-dioxolane (CAS 2221812-33-3)
- Antistasin-Related Peptide (CAS 161561-46-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com