Levothyroxine EP Impurity A CAS 6893-02-3
| CAS No. | 6893-02-3 |
| Molecular Formula | C15H12I3NO4 |
| Molecular Weight | 650.97 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Levothyroxine EP Impurity A (C15H12I3NO4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, iodine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Levothyroxine EP Impurity A (CAS 6893-02-3) is a certified pharmaceutical impurity reference standard with the molecular formula C15H12I3NO4 and a molecular weight of 650.97 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Levothyroxine EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H12I3NO4 |
| Molecular Weight | 650.97 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 1 |
Related Levothyroxine Standards
- Levothyroxine EP Impurity K (CAS 5817-39-0)
- Levothyroxine EP Impurity K (R-Isomer) (CAS 66701-15-3)
- Levothyroxine Impurity 15 (CAS CATO-C4X-167815)
- Levothyroxine Impurity 14 (CAS 3914-31-6)
- Levothyroxine Impurity 17 (CAS 51-26-3)
- Levothyroxine EP Impurity C (CAS 51-24-1)
- Levothyroxine Impurity 16 (CAS 92905-78-7)
- Levothyroxine EP Impurity B (CAS 1628720-66-0)
Recommended Standards
- Liothyronine related impurity, (R)-2-amino (CAS 5714-08-9)
- Uvarimacrophin A (CAS 167425-75-4)
- N-[(8α,9R)-6'-Methoxycinchonan-9-yl]-N'-[[(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenyl]methyl]thiourea (CAS 1314080-83-5)
- Mn(III) Protoporphyrin IX chloride (CAS 120389-54-0)
- Etizolam Impurity 31 (CAS CATO-C4X-350931)
- Epinephrine Impurity 92 (CAS CATO-C4X-184992)
- Tembotrione Impurity 2 (CAS 1429656-75-6)
- Teprenone impurity 47 (CAS CATO-C4X-208147)
- N-Chloro-p-toluenesulfonamide (CAS 144-86-5)
- 2-Ethoxy-6-fluoro-benzonitrile 2-ethoxy-6-fluorobenzonitrile 2-fluoro-6-ethoxybenzonitrile 119584-73-5 (CAS 119584-73-5)
- 1,4-Dimethylpyrazole (CAS 1072-68-0)
- Tandutinib Impurity 1 (CAS 288383-74-4)
- 2-((5-(2-Bromophenyl)-1,3,4-oxadiazol-2-yl)thio)-N-(2-ethylphenyl)acetamide (CAS 332154-66-2)
- Semaglutide impurity 203 (CAS CATO-C4X-2226203)
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