Levothyroxine EP Impurity K (R-Isomer) CAS 66701-15-3
| CAS No. | 66701-15-3 |
| Molecular Formula | C15H12I3NO4 |
| Molecular Weight | 650.97 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, iodine substitution, Levothyroxine EP Impurity K (R-Isomer) is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 650.97 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Levothyroxine EP Impurity K (R-Isomer) (CAS 66701-15-3, C15H12I3NO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Levothyroxine EP Impurity K (R-Isomer) under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C15H12I3NO4 |
| Molecular Weight | 650.97 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 1 |
Related Levothyroxine Standards
- Levothyroxine EP Impurity A (CAS 6893-02-3)
- Levothyroxine EP Impurity K (CAS 5817-39-0)
- Levothyroxine Impurity 15 (CAS CATO-C4X-167815)
- Levothyroxine Impurity 14 (CAS 3914-31-6)
- Levothyroxine Impurity 17 (CAS 51-26-3)
- Levothyroxine EP Impurity C (CAS 51-24-1)
- Levothyroxine Impurity 16 (CAS 92905-78-7)
- Levothyroxine EP Impurity B (CAS 1628720-66-0)
Recommended Standards
- Mn(III) Protoporphyrin IX chloride (CAS 120389-54-0)
- (Z)-Thiobis(ethane-2,1-diyl) dioleate (CAS 65808-58-4)
- Liothyronine related impurity, (R)-2-amino (CAS 5714-08-9)
- Cholesteryl elaidate (CAS 19485-76-8)
- FCN437 Impurity 7 (CAS CATO-C4X-33247)
- Carteolol Impurity 20 (CAS CATO-C4X-228720)
- Clopidogrel Impurity 24 (CAS CATO-C4X-102924)
- 2-((1,3,4-Thiadiazol-2-yl)amino)-5-benzylidenethiazol-4(5H)-one (CAS 89335-26-2)
- Ethyl 2-formyl-5-methyl-1,3-thiazole-4-carboxylate (CAS 1282549-65-8)
- cis-hexahydro-1H-thieno[3,4-c]pyrrole hydrochloride (CAS 179339-70-9)
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- Boc-Cholecystokinin Octapeptide (desulfated) (A-1295.0001) (CAS 25687-34-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com