Lifitegrast Impurity 42 CAS 588703-29-1
| CAS No. | 588703-29-1 |
| Molecular Formula | C10H8O3 |
| Molecular Weight | 176.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C10H8O3, Lifitegrast Impurity 42 contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 176.17 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Lifitegrast Impurity 42 (CAS 588703-29-1, C10H8O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H8O3 |
| Molecular Weight | 176.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
Related Lifitegrast Standards
- Lifitegrast Impurity 168 (CAS CATO-C4X-2409168)
- Lifitegrast Impurity N60 (CAS 933752-32-0)
- Lifitegrast Impurity 10 (CAS 77095-51-3)
- Lifitegrast Impurity 165 (CAS CATO-C4X-2409165)
- Lifitegrast Impurity 19 (CAS 1289646-90-7)
- Lifitegrast Impurity N68 (CAS 89315-56-0)
- Lifitegrast Impurity 108 (CAS CATO-C4X-2409108)
- Lifitegrast Impurity 109 (CAS CATO-C4X-2409109)
Recommended Standards
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- 2,3-Dimethyl-2,3-dinitrobutane (CAS 3964-18-9)
- Regadenoson Impurity 36 (CAS 871301-32-5)
- Perindopril Impurity 76 (CAS CATO-C4X-125276)
- CAS 2480056-23-1 (CAS 2480056-23-1)
- Ramosetron impurity 32 (CAS 167545-91-7)
- 1-((2,4-Dimethoxyphenyl)sulfonyl)piperazine (CAS 524711-16-8)
- 2-Amino-N,N-dimethylthiazole-4-carboxamide (CAS 827588-49-8)
- 2-Hydroxy-5-methylphenyl benzoate (CAS 10268-64-1)
- N-(2-Hydroxy-1,1-dimethylethyl)-4,5,6,7-tetra-hydro-1H-pyrazolo[4,3-c]pyridine-3-carboxamide HCl (CAS 1220030-25-0)
- 2-((2-((4-Bromo-2-methylphenyl)amino)-2-oxoethyl)thio)acetic acid (CAS 483312-15-8)
- SSR 69071 (CAS 344930-95-6)
- Liraglutide(3-31)TFA Salt (CAS CATO-C4X-19921)
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