Midazolam Impurity 41 CAS 59468-85-8
| CAS No. | 59468-85-8 |
| Molecular Formula | C18H13ClFN3O |
| Molecular Weight | 341.77 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Midazolam Impurity 41 (CAS 59468-85-8), a pharmacopoeial impurity reference standard (molecular formula C18H13ClFN3O, MW 341.77 g/mol) used for the identification and quantification of trace impurities in APIs.
Midazolam Impurity 41 (C18H13ClFN3O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Midazolam Impurity 41 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H13ClFN3O |
| Molecular Weight | 341.77 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Midazolam Standards
- Midazolam Impurity 1 (CAS 59468-90-5)
- Midazolam EP Impurity D (CAS 59468-83-6)
- Midazolam Impurity 32 (CAS CATO-C4X-150932)
- Midazolam Impurity 33 (CAS CATO-C4X-150933)
- Midazolam EP Impurity I (CAS 112811-67-3)
- Midazolam Impurity 25 (CAS CATO-C4X-150925)
- Midazolam Impurity 13 (CAS CATO-C4X-150913)
- Midazolam-d5 (Major) Discontinued See M343003 (CAS 395067-42-2)
Recommended Standards
- 5-Allyl-6-chloro-N-(2-fluoro-4-(methylsulfonyl)phenyl)pyrimidin-4-amine (CAS 1001397-14-3)
- 4-(2-(2-(2-Chlorophenyl)-5-methyloxazol-4-yl)ethoxy)benzaldehyde (CAS 103789-58-8)
- N'-[(1Z)-(2-Chloro-4-fluorophenyl)methylidene]-2-(1H-pyrrol-1-yl)benzohydrazide (CAS 478063-25-1)
- 2-(4-(Tert-butoxycarbonyl)piperazin-1-yl)-3-chloroisonicotinic acid (CAS 1135283-34-9)
- Acetylcysteine Impurity 26 (CAS CATO-C4X-153226)
- Amisulpride Impurity 41 (CAS 2230058-95-2)
- Terbutaline EP Impurity D (Methylsulfonate) (CAS 94109-61-2(Free Base))
- 4-(5,6-Dihydro-8H-imidazo[2,1-c][1,4]oxazin-3-yl)aniline (CAS 1428233-69-5)
- N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)acrylamide (CAS 1869057-83-9)
- (1R,3R)-3-amino-2,2-dimethylcyclobutane-1-carboxylic acid (CAS 1932587-58-0)
- 3-Amino-1-(furan-2-ylmethyl)urea (CAS 1094481-44-3)
- Dimethyl acetylphosphonate (CAS 17674-28-1)
- 2,2′-(2-Methyl-1,3-phenylene)bis[4,5-dihydro-4,4-dimethyloxazole] (CAS 64682-39-9)
- Liraglutide(8-31)TFA Salt (CAS CATO-C4X-19922)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com