Bromfenac Impurity 1 CAS 61941-62-6
| CAS No. | 61941-62-6 |
| Molecular Formula | C15H11ClNO3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Bromfenac Impurity 1.
CATO supplies Bromfenac Impurity 1 (CAS 61941-62-6), a pharmacopoeial impurity reference standard (molecular formula C15H11ClNO3Na, MW 311.70 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Bromfenac Impurity 1 (C15H11ClNO3Na) contains a salt form, a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.5, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 311.70 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H11ClNO3 Na |
| Molecular Weight | 311.70 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1974 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Bromfenac Standards
- Bromfenac Impurity 30 (CAS 102414-22-2)
- Bromfenac Sodium Sesquihydrate (CAS 120638-55-3)
- Bromfenac Impurity 30 (CAS 1279501-08-4)
- Bromfenac Impurity 3 (CAS 1391052-54-2)
- Bromfenac Impurity 76 (CAS 1623751-93-8)
- Bromfenac Impurity 33 (CAS 1644279-16-2)
- Bromfenac Impurity N2 (CAS 1798431-98-7)
- Bromfenac N-β-D-Glucoside (CAS 212266-82-5)
Recommended Standards
- Nicorandil EP Impurity C HCl (CAS 72676-16-5)
- LCZ-696 Impurity 11 (CAS CATO-C4X-169611)
- Istradefylline Impurity 29 (CAS 5759-63-7)
- [4-(Isopropylthio)phenyl]acetyl chloride (CAS 1170785-23-5)
- 1-(Pyrrolidin-2-ylmethyl)-3-(trifluoromethyl)-1H-pyrazole (CAS 1248279-42-6)
- 1-(4-Hydroxyphenyl)-2-methylpropan-1-one (CAS 34917-91-4)
- 3-(3-Methylisoxazol-5-yl)acrylamide (CAS 71865-09-3)
- 5-Chlorobenzoxazole-2-methanamine (CAS 936074-77-0)
- Benzyl (E)-2-(3-(1H-imidazol-1-yl)prop-1-en-1-yl)pyrrolidine-1-carboxylate (CAS 956627-43-3)
- Semaglutide impurity 200 (CAS CATO-C4X-2226200)
Why CATO?
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