Metoprolol EP Impurity H CAS 62572-94-5
| CAS No. | 62572-94-5 |
| Molecular Formula | C14H23NO3 |
| Molecular Weight | 253.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Metoprolol EP Impurity H.
CATO supplies Metoprolol EP Impurity H (CAS 62572-94-5), a pharmacopoeial impurity reference standard (molecular formula C14H23NO3, MW 253.34 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Metoprolol EP Impurity H is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 253.34 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H23NO3 |
| Molecular Weight | 253.34 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1974 |
| Nitrogen Atoms | 1 |
Related Metoprolol Standards
- Metoprolol EP Impurity A (CAS 109632-08-8)
- Metoprolol Impurity 10 (CAS 131564-70-0)
- Metoprolol Impurity 47 (CAS CATO-C4X-136747)
- Metoprolol USP Related Compound B (CAS 56718-76-4)
- Metoprolol Impurity 51 (CAS 2517349-25-4)
- Metoprolol impurity 1 (CAS 150332-88-0)
- Metoprolol Impurity 2 (Mixture of Z and E Isomers) (CAS 82961-02-2)
- Metoprolol Impurity 44 (CAS CATO-C4X-136744)
Recommended Standards
- Mianserin Impurity 53 (CAS CATO-C4X-136953)
- Fluoxetine Impurity 35 (CAS 21970-65-0)
- Formoterol Impurity 95 (CAS CATO-C4X-152595)
- Salbutamol EP Impurity A (CAS 870076-72-5)
- Baxdrostat Impurity 8 (CAS 3059712-82-9)
- Bosutinib Impurity 11 (CAS CATO-C4X-184711)
- Naproxen EP Impurity C (CAS 84236-26-0)
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- 1-(4-Isopropylphenyl)-3-methylbutan-1-one (CAS 1154333-43-3)
- (R)-2-amino-N,2-diphenylacetamide (CAS 1035968-08-1)
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- 2-(3-(Chlorosulfonyl)-2,4,6-trimethylphenyl)acetic acid (CAS 1461706-50-2)
- 1-{1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl}piperidin-4-one (CAS 1094236-86-8)
- Antifreeze Polypeptide 6 (winter flounder) trifluoroacetate salt (CAS 122604-16-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com