Nilotinib CAS 641571-10-0
| CAS No. | 641571-10-0 |
| Molecular Formula | C28H22F3N7O |
| Molecular Weight | 529.52 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Nilotinib.
Nilotinib (CAS 641571-10-0) is a high-purity analytical reference standard with the molecular formula C28H22F3N7O and a molecular weight of 529.52 g/mol.
Nilotinib (C28H22F3N7O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Nilotinib meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C28H22F3N7O |
| Molecular Weight | 529.52 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 7 |
Related Nilotinib Standards
- Nilotinib Hydrochloride Monohydrate EP Impurity H (CAS 641571-15-5)
- Nilotinib Impurity 9 (CAS 641571-05-3)
- Nilotinib Impurity 42 (CAS CATO-C4X-125642)
- Nilotinib-d3 (CAS 1215678-43-5)
- Nilotinib-d6 (CAS 1268356-17-7)
- Nilotinib Impurity 43 (CAS CATO-C4X-125643)
- Nilotinib Hydrochloride Monohydrate EP Impurity F (CAS 2119583-24-1)
- Nilotinib EP Impurity E (CAS 2119583-26-3)
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