Cinacalcet Impurity 38 CAS 67801-07-4
| CAS No. | 67801-07-4 |
| Molecular Formula | C10H7F3O2 |
| Molecular Weight | 216.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Cinacalcet Impurity 38 (CAS 67801-07-4, C10H7F3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Cinacalcet Impurity 38 (C10H7F3O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H7F3O2 |
| Molecular Weight | 216.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | F-containing |
Related Cinacalcet Standards
- Cinacalcet Impurity 45 (CAS 16642-92-5)
- Cinacalcet Impurity 46 (CAS 2062-25-1)
- Cinacalcet Impurity 113 (CAS 67646-72-4)
- Cinacalcet Impurity 3 (CAS 93040-58-5)
- Cinacalcet Impurity 7 (CAS 585-50-2)
- Cinacalcet Impurity 33 (CAS 94022-99-8)
- Cinacalcet Impurity 34 (CAS 53473-36-2)
- Cinacalcet Impurity 69 (CAS 114748-82-2)
Recommended Standards
- Celecoxib Impurity 37 (CAS 326-06-7)
- 2-(4-(trifluoromethyl)phenyl)malonaldehyde 2-(4-Trifluoromethylphenyl)malondialdehyde 2-(4-trifluoromethylphenyl)malonaldehyde 2-[4-(trifluoromethyl)phenyl]malonaldehyde 493036-50-3 (CAS 493036-50-3)
- DiiSopropyldifluoromethylphosphonate (CAS 681-80-1)
- Sitagliptin Impurity 166 (CAS 2226094-64-8)
- Ziprasidone EP Impurity C (CAS 1159977-64-6)
- Palbociclib Impurity 133 (CAS CATO-C4X-1125133)
- Bilastine impurity 104 (CAS 1368721-60-1)
- 2-(3-Methoxyphenyl)hydrazine-1-carbothioamide (CAS 1215296-81-3)
- 2-((Cyclohex-3-en-1-ylmethyl)amino)butan-1-ol (CAS 1042553-15-0)
- 5-(2-Formyl-1H-pyrrol-1-yl)-1-phenyl-1H-pyrazole-4-carboxylic acid (CAS 847021-86-7)
- N-(2-Bromophenyl)-2-((5-(((4-ethoxyphenyl)amino)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 445229-36-7)
- Ethyl 5-(4-chloro-2-fluorophenoxy)pentanoate (CAS 1443333-88-7)
- (5-Methyl-2-oxo-1,3-benzoxazol-3(2H)-yl)acetic acid (CAS 767304-83-6)
- Liraglutide Impurity 20 TFA Salt (CAS CATO-C4X-199220)
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