Cinacalcet Impurity 34 CAS 53473-36-2
| CAS No. | 53473-36-2 |
| Molecular Formula | C10H9F3O2 |
| Molecular Weight | 218.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 218.17 g/mol gives Cinacalcet Impurity 34 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Cinacalcet Impurity 34 (CAS 53473-36-2, C10H9F3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, Cinacalcet Impurity 34 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 218.17 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Cinacalcet Impurity 34 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H9F3O2 |
| Molecular Weight | 218.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
| Halogen Content | F-containing |
Related Cinacalcet Standards
- Cinacalcet Impurity 7 (CAS 585-50-2)
- Cinacalcet Impurity 33 (CAS 94022-99-8)
- Cinacalcet Impurity 113 (CAS 67646-72-4)
- Cinacalcet Impurity 38 (CAS 67801-07-4)
- Cinacalcet Impurity 45 (CAS 16642-92-5)
- Cinacalcet Impurity 46 (CAS 2062-25-1)
- Cinacalcet Impurity 3 (CAS 93040-58-5)
- Cinacalcet Impurity 47 (CAS 82258-76-2)
Recommended Standards
- 2-((3-(Trifluoromethyl)phenoxy)methyl)oxirane (CAS 585-45-5)
- Quinoxaline-5,8-dicarboxylic acid (CAS 569660-09-9)
- Ivacaftor impurity 17 (CAS CATO-C4X-296417)
- Quinoxaline-2,3-dicarboxylic acid (CAS 6924-99-8)
- Bevantolol Impurity 20 (CAS CATO-C4X-241120)
- Ibuprofen Impurity 108 (CAS CATO-C4X-1082108)
- Anastrozole Impurity 33 (CAS CATO-C4X-123933)
- tert-butyl N-[(tert-butoxy)carbonyl]-N-(3-oxobutyl)carbamate (CAS 2140326-62-9)
- 5-Bromo-2-(4-ethylpiperazin-1-yl)pyrimidine (CAS 950410-05-6)
- (2,5-Dimethylphenyl)(4-(pyrrolidin-1-ylmethyl)phenyl)methanone (CAS 898776-47-1)
- Ethyl 6-(4-methoxyphenyl)-2-methylnicotinate (CAS 2004-63-9)
- N-(4-Methylphenyl)-2-(4-oxo-2-thiazolidinylidene)acetamide (CAS 730951-05-0)
- n1,n1-Diethyl-n2-(furan-2-ylmethyl)ethane-1,2-diamine (CAS 99991-35-2)
- Semaglutide Impurity 161 (x TFA Salt) (CAS CATO-C4X-2226161)
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