Cinacalcet Impurity 33 CAS 94022-99-8
| CAS No. | 94022-99-8 |
| Molecular Formula | C10H9F3O2 |
| Molecular Weight | 218.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Cinacalcet Impurity 33.
As a process- or degradation-related impurity, Cinacalcet Impurity 33 (CAS 94022-99-8, C10H9F3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Cinacalcet Impurity 33 (C10H9F3O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 218.17 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Cinacalcet Impurity 33 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H9F3O2 |
| Molecular Weight | 218.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1983 |
| Halogen Content | F-containing |
Related Cinacalcet Standards
- Cinacalcet Impurity 7 (CAS 585-50-2)
- Cinacalcet Impurity 34 (CAS 53473-36-2)
- Cinacalcet Impurity 113 (CAS 67646-72-4)
- Cinacalcet Impurity 38 (CAS 67801-07-4)
- Cinacalcet Impurity 45 (CAS 16642-92-5)
- Cinacalcet Impurity 46 (CAS 2062-25-1)
- Cinacalcet Impurity 3 (CAS 93040-58-5)
- Cinacalcet Impurity 47 (CAS 82258-76-2)
Recommended Standards
- Quinoxaline-5,8-dicarboxylic acid (CAS 569660-09-9)
- Quinoxaline-2,3-dicarboxylic acid (CAS 6924-99-8)
- 2-((3-(Trifluoromethyl)phenoxy)methyl)oxirane (CAS 585-45-5)
- Quinazoline-4,8-dicarboxylic acid (CAS 569660-10-2)
- N-Nitroso Cinacalcet Impurity 3 (CAS CATO-C4X-105973)
- Ledipasvir Impurity 22 (CAS CATO-C4X-331322)
- Epinephrine /Adrenaline Impurity 130 (CAS CATO-C4X-1849130)
- Ethyl (2E)-2-(2,5-difluorobenzenesulfonyl)-3-[(4-methoxyphenyl)amino]prop-2-enoate (CAS 1327176-78-2)
- tert-Butyl (2-formylfuran-3-yl)carbamate (CAS 889088-96-4)
- 2-Phenyldihydro-2H-pyran-4(3H)-one (CAS 147688-62-8)
- 2-(1-(2-Chloro-6-cyanophenyl)-1H-pyrrol-2-yl)-N,N-diethyl-2-oxoacetamide (CAS 866043-06-3)
- 4-Amino-2-mercapto-6-methyl-pyrimidine-5-carbonitrile (CAS 160457-21-6)
- 5-Amino-1-ethylpiperidin-2-one (CAS 1334146-74-5)
- Semaglutide Impurity 140 (CAS CATO-C4X-2226140)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com