Cinacalcet Impurity 45 CAS 16642-92-5
| CAS No. | 16642-92-5 |
| Molecular Formula | C10H7F3O2 |
| Molecular Weight | 216.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Cinacalcet Impurity 45 is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Cinacalcet Impurity 45 (CAS 16642-92-5, C10H7F3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C10H7F3O2, Cinacalcet Impurity 45 contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 216.16 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H7F3O2 |
| Molecular Weight | 216.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | F-containing |
Related Cinacalcet Standards
- Cinacalcet Impurity 38 (CAS 67801-07-4)
- Cinacalcet Impurity 46 (CAS 2062-25-1)
- Cinacalcet Impurity 113 (CAS 67646-72-4)
- Cinacalcet Impurity 3 (CAS 93040-58-5)
- Cinacalcet Impurity 7 (CAS 585-50-2)
- Cinacalcet Impurity 33 (CAS 94022-99-8)
- Cinacalcet Impurity 34 (CAS 53473-36-2)
- Cinacalcet Impurity 69 (CAS 114748-82-2)
Recommended Standards
- Celecoxib Impurity 37 (CAS 326-06-7)
- Sitagliptin Impurity 166 (CAS 2226094-64-8)
- 2-(4-(trifluoromethyl)phenyl)malonaldehyde 2-(4-Trifluoromethylphenyl)malondialdehyde 2-(4-trifluoromethylphenyl)malonaldehyde 2-[4-(trifluoromethyl)phenyl]malonaldehyde 493036-50-3 (CAS 493036-50-3)
- Sitagliptin Impurity 167 (CAS 1840966-95-1)
- Lidocaine Impurity 22 (CAS 17122-33-7)
- Pregabalin Impurity 25 (CAS CATO-C4X-131225)
- Pitavastatin Sodium Salt Monohydrate (CAS CATO-C4X-1037123)
- 5-(4-Fluorophenyl)pentan-2-ol (CAS 63416-41-1)
- 5-Nitrobicyclo[2.2.1]hept-2-ene (CAS 768-16-1)
- Amlodipine Impurity 79 (CAS 3516-73-2)
- Amikacin hydrate (CAS 1257517-67-1)
- 6-Hydroxy-1-Phenyl-Naphthalene (CAS 156152-21-5)
- 1-(4-Nitrophenyl)-4-(3-(trifluoromethyl)phenyl)piperazine (CAS 1287096-67-6)
- Semaglutide Impurity 140 (CAS CATO-C4X-2226140)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com