Methotrexate Dimethylamide CAS 71074-44-7
| CAS No. | 71074-44-7 |
| Molecular Formula | C22H27N9O4 |
| Molecular Weight | 481.51 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Methotrexate Dimethylamide (CAS 71074-44-7) is a high-purity analytical reference standard with the molecular formula C22H27N9O4 and a molecular weight of 481.51 g/mol.
Structurally, Methotrexate Dimethylamide (C22H27N9O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 481.51 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H27N9O4 |
| Molecular Weight | 481.51 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1977 |
| Nitrogen Atoms | 9 |
Related Methotrexate Standards
- Methotrexate Impurity 18 (CAS CATO-C4X-115418)
- Methotrexate impurity N3 (CAS 65148-64-3)
- Methotrexate EP Impurity J (CAS 34378-65-9)
- Methotrexate Impurity 61 (CAS 65148-63-2)
- Methotrexate impurity 50 (CAS CATO-C4X-115450)
- Methotrexate impurity 53 (CAS CATO-C4X-115453)
- Methotrexate-d (CAS 432545-60-3)
- Methotrexate Impurity 28 (CAS 5939-37-7)
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Why CATO?
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