Pralatrexate Impurity 1 CAS 716-74-5
| CAS No. | 716-74-5 |
| Molecular Formula | C7H6N6O2 |
| Molecular Weight | 206.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Pralatrexate Impurity 1 (CAS 716-74-5, C7H6N6O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Pralatrexate Impurity 1 (C7H6N6O2) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H6N6O2 |
| Molecular Weight | 206.16 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 6 |
Related Pralatrexate Standards
- Pralatrexate Impurity 2 (CAS 2028268-08-6)
- Pralatrexate Impurity 4 (CAS 146464-93-9)
- Pralatrexate Impurity 2 (CAS 52454-37-2)
- Pralatrexate-D5 (CAS 146464-95-1)
- R-Pralatrexate (CAS 1320211-70-8)
- S-Pralatrexate (CAS 1320211-69-5)
- Pralatrexate Impurity 3 (CAS CATO-C4X-22143)
- Pralatrexate Impurity 8 (CAS 374777-77-2)
Recommended Standards
- 332909-71-4 2-hydroxy-4-(1H-tetrazol-1-yl)benzoic acid DTXSID30357635 (CAS 332909-71-4)
- Pretomanid Impurity 30 (CAS 2923894-84-0)
- Methyl 6-amino-5-cyano-3-formylpyrazine-2-carboxylate (CAS 79722-45-5)
- 4-Fluoro-1-hydroxy-2-naphthoic acid (CAS 1000386-61-7)
- Sulfadimethoxine Impurity 21 (CAS CATO-C4X-150421)
- Captopril Impurity 27 (CAS CATO-C4X-119027)
- Losartan Impurity 48 (CAS CATO-C4X-168348)
- (R)-2-(o-tolyl)piperidine (CAS 742044-13-9)
- 4,5,6,7-Tetrahydro-1-benzofuran-4-amine (CAS 389795-57-7)
- Tamoxifen Impurity 18 (CAS 123091-15-6)
- 5-Hydroxy-2-nitrobenzonitrile (CAS 13589-74-7)
- 2-Methyl-3-phenoxyquinoline (CAS 92855-35-1)
- 7-Chloro-4-(4-BOC-piperazino)quinoline (CAS 1235972-74-3)
- Peptide 441 (CAS CATO-CPTD788441)
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